[HTML][HTML] Drug resistance and treatment failure in leishmaniasis: A 21st century challenge

A Ponte-Sucre, F Gamarro, JC Dujardin… - PLoS neglected …, 2017 - journals.plos.org
Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …

Recent advances and new strategies on leishmaniasis treatment

BM Roatt, JM de Oliveira Cardoso… - Applied Microbiology …, 2020 - Springer
Leishmaniasis is one of the most important tropical neglected diseases according to the
World Health Organization. Even after more than a century, we still have few drugs for the …

Diagnosis and treatment of leishmaniasis: clinical practice guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical …

N Aronson, BL Herwaldt, M Libman… - Clinical infectious …, 2016 - academic.oup.com
It is important to realize that leishmaniasis guidelines cannot always account for individual
variation among patients. They are not intended to supplant physician judgment with respect …

Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis

TPC Dorlo, M Balasegaram, JH Beijnen… - Journal of …, 2012 - academic.oup.com
Miltefosine is an alkylphosphocholine drug with demonstrated activity against various
parasite species and cancer cells as well as some pathogenic bacteria and fungi. For 10 …

Recent development of visceral leishmaniasis treatments: successes, pitfalls, and perspectives

F Alves, G Bilbe, S Blesson, V Goyal… - Clinical microbiology …, 2018 - Am Soc Microbiol
Research in visceral leishmaniasis in the last decade has been focused on how better to
use the existing medicines as monotherapy or in combination. Systematic research by …

[HTML][HTML] Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis

AS Nagle, S Khare, AB Kumar, F Supek… - Chemical …, 2014 - ACS Publications
Leishmaniasis is a parasitic disease that presents four main clinical syndromes: cutaneous
leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), visceral leishmaniasis/kala azar …

An update on pharmacotherapy for leishmaniasis

S Sundar, J Chakravarty - Expert opinion on pharmacotherapy, 2015 - Taylor & Francis
Introduction: Leishmaniasis broadly manifests as visceral leishmaniasis (VL), cutaneous
leishmaniasis (CL) and mucocutaneous leishmaniasis. The treatment of leishmaniasis is …

Chemotherapy of leishmaniasis: present challenges

SRB Uliana, CT Trinconi, AC Coelho - Parasitology, 2018 - cambridge.org
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

Current and emerging medications for the treatment of leishmaniasis

J Chakravarty, S Sundar - Expert opinion on pharmacotherapy, 2019 - Taylor & Francis
Introduction: Leishmaniasis is a vector-borne neglected tropical disease which manifests as
visceral leishmaniasis (VL), cutaneous leishmaniasis (CL), and mucocutaneous …

Leishmaniasis drug discovery: recent progress and challenges in assay development

B Zulfiqar, TB Shelper, VM Avery - Drug discovery today, 2017 - Elsevier
Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …