[HTML][HTML] Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

[HTML][HTML] Recent advances in identifying protein targets in drug discovery

J Ha, H Park, J Park, SB Park - Cell chemical biology, 2021 - cell.com
Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …

[HTML][HTML] Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis

B He, H Wang, G Liu, A Chen, A Calvo, Q Cai… - Nature …, 2023 - nature.com
Small RNAs (sRNAs) of the fungal pathogen Botrytis cinerea can enter plant cells and hijack
host Argonaute protein 1 (AGO1) to silence host immunity genes. However, the mechanism …

Extracellular pectin-RALF phase separation mediates FERONIA global signaling function

MCJ Liu, FLJ Yeh, R Yvon, K Simpson, S Jordan… - Cell, 2024 - cell.com
Summary The FERONIA (FER)-LLG1 co-receptor and its peptide ligand RALF regulate
myriad processes for plant growth and survival. Focusing on signal-induced cell surface …

Insight into the role of clathrin‐mediated endocytosis inhibitors in SARS‐CoV‐2 infection

SS Alkafaas, AM Abdallah, S Ghosh… - Reviews in Medical …, 2023 - Wiley Online Library
Emergence of SARS‐CoV‐2 variants warrants sustainable efforts to upgrade both the
diagnostic and therapeutic protocols. Understanding the details of cellular and molecular …

Clathrin-mediated endocytosis facilitates the internalization of Magnaporthe oryzae effectors into rice cells

E Oliveira-Garcia, TM Tamang, J Park, M Dalby… - The Plant …, 2023 - academic.oup.com
Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and
control plant processes needed for infection. Little is known about the mechanism by which …

[HTML][HTML] The chemical inhibitors of endocytosis: from mechanisms to potential clinical applications

OK Szewczyk-Roszczenko, P Roszczenko… - Cells, 2023 - mdpi.com
Endocytosis is one of the major ways cells communicate with their environment. This
process is frequently hijacked by pathogens. Endocytosis also participates in the oncogenic …

[HTML][HTML] Role of clathrin and dynamin in clathrin mediated endocytosis/synaptic vesicle recycling and implications in neurological diseases

KL Prichard, NS O'Brien, SR Murcia… - Frontiers in Cellular …, 2022 - frontiersin.org
Endocytosis is a process essential to the health and well-being of cell. It is required for the
internalisation and sorting of “cargo”—the macromolecules, proteins, receptors and lipids of …

[HTML][HTML] IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses

M Clement, JL Forbester, M Marsden… - Nature …, 2022 - nature.com
Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that limits viral
pathogenesis and exerts poorly understood immunoregulatory functions. Here, using human …

Mass spectrometric exploration of phytohormone profiles and signaling networks

Y Chen, Y Wang, X Liang, Y Zhang, AR Fernie - Trends in Plant Science, 2023 - cell.com
Phytohormones have crucial roles in plant growth, development, and acclimation to
environmental stress; however, measuring phytohormone levels and unraveling their …