The Notch signaling pathway is an ancient and highly conserved signaling pathway that
controls cell fate specification and tissue patterning in the embryo and in the adult. Region …

The major arteries and veins of the vertebrate circulatory system are formed early in
embryonic development, before the onset of circulation, following de novo aggregation of …

Notch is an evolutionarily conserved local cell signaling mechanism that participates in a
variety of cellular processes: cell fate specification, differentiation, proliferation, apoptosis …

Ventricular chamber morphogenesis, first manifested by trabeculae formation, is crucial for
cardiac function and embryonic viability and depends on cellular interactions between the …

Alagille syndrome (ALGS) is an autosomal dominant, multisystem disorder with variable
phenotypic penetrance that was first described in 1969 by Daniel Alagille. Initial diagnosis …

The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the
past centered on Notch function in cardiomyocytes. However, recent advances demonstrate …

Snail family proteins are key regulators of epithelial-mesenchymal transition, but their role in
endothelial-to-mesenchymal transition (EMT) is less well studied. We show that Slug, a Snail …

Alagille syndrome is a human autosomal dominant developmental disorder characterized by
liver, heart, eye, skeletal, craniofacial and kidney abnormalities. Alagille syndrome is caused …

Notch signaling is an extremely conserved and widely used mechanism regulating cell fate
in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) …

The Notch ligand Jagged1 (Jag1) is essential for vascular remodeling and has been linked
to congenital heart disease in humans, but its precise role in various cell types of the …