Angelman Syndrome (AS) is characterized by severe developmental delays including
marked speech impairment, movement abnormalities (ataxia, tremor), and unique behaviors …

This study presents a broad overview of health issues and psychomotor development of 100
children with Angelman syndrome (AS), seen at the ENCORE Expertise Center for AS in …

The UBE3A gene is part of the chromosome 15q11-q13 region that is frequently deleted or
duplicated, leading to several neurodevelopmental disorders (NDD). Angelman syndrome …

Background Clinicians have qualitatively described rhythmic delta activity as a prominent
EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be …

Background Angelman syndrome (AS) is a rare neurogenetic disorder present in
approximately 1/12,000 individuals and characterized by developmental delay, cognitive …

Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are genetic imprinting
disorders resulting from absent or reduced expression of paternal or maternal genes in …

We describe the development of 236 children with Angelman syndrome (AS) using the
Bayley Scales of Infant and Toddler Development, Third Edition. Multilevel linear mixed …

Loss of the maternal UBE3A allele causes Angelman syndrome (AS), a debilitating
neurodevelopmental disorder. Here, we devised an AS treatment strategy based on …

Angelman syndrome (AS) is a rare neurodevelopmental disease that is caused by the loss
of function of the maternal copy of ubiquitin–protein ligase E3A (UBE3A) on the …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by a loss of the
maternally‐inherited UBE3A; the paternal UBE3A is silenced in neurons by a mechanism …