The chemokine interferon-γ inducible protein 10 kDa (CXCL10) is a member of the CXC
chemokine family which binds to the CXCR3 receptor to exert its biological effects. CXCL10 …

Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …

Clear cell renal cell carcinoma (ccRCC) is histologically defined by its lipid and glycogen-
rich cytoplasmic deposits. Alterations in the VHL tumor suppressor stabilizing the hypoxia …

Metabolic reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC).
Here we investigated metabolic dependencies in a panel of ccRCC cell lines using nutrient …

The de novo synthesis of the nonessential amino acid serine is often upregulated in cancer.
In this study, we demonstrate that the serine catabolic enzyme, mitochondrial serine …

Circular RNAs (circRNAs) are reported to act as important regulators in cancers. CircRNA
RAPGEF5 (cRAPGEF5) is derived from exons 2–6 of the RAPGEF5 gene and may promote …

Background Overexpression of NPM1 can promote the growth and proliferation of various
tumor cells. However, there are few studies on the comprehensive analysis of NPM1 in lung …

Many cancer cells depend on glutamine as they use the glutaminolysis pathway to generate
building blocks and energy for anabolic purposes. As a result, glutamine transporters are …

The hypoxia-inducible transcription factors (HIFs) directly and indirectly mediate cellular
adaptation to reduced oxygen tensions. Recent studies have shown that the histone …

CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-
coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and …