Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Osteoarthritis is a disease that impacts millions around the world, leading to significant
financial and medical burden for patients and the healthcare system. However, no effective …

Background Osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases and is
the leading cause of pain and disability in the aged population. However, the underlying …

Amino acid metabolism regulates essential cellular functions, not only by fueling protein
synthesis, but also by supporting the biogenesis of nucleotides, redox factors and lipids …

Osteoarthritis (OA) is a joint disease affecting millions of patients worldwide. During OA
onset and progression, the articular cartilage is destroyed, but the underlying complex …

Osteoarthritis (OA) is the leading joint disease characterized by cartilage destruction and
loss of mobility. Accumulating evidence indicates that the incidence and severity of OA …

Osteoarthritis (OA) is an entire joint disease with pathological alteration in both articular
cartilage and subchondral bone. It has been recognized recently the association between …

Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing
evidence showed that glucose metabolism impacts joint homeostasis and an imbalance …

Osteoarthritis (OA) is a common degenerative joint disease that can affect almost any joint,
mainly resulting in joint dysfunction and pain. Worldwide, OA affects more than 240 million …

Glycolysis is central to homeostasis of nucleus pulposus (NP) cells in the avascular
intervertebral disc. Since the glucose transporter, GLUT1, is a highly enriched phenotypic …