Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors

I Jurado-Martín, M Sainz-Mejías… - International journal of …, 2021 - mdpi.com
Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

Pseudomonas aeruginosa: Infections, Animal Modeling, and Therapeutics

SJ Wood, TM Kuzel, SH Shafikhani - Cells, 2023 - mdpi.com
Pseudomonas aeruginosa is an important Gram-negative opportunistic pathogen which
causes many severe acute and chronic infections with high morbidity, and mortality rates as …

Antibiotic resistance in Pseudomonas aeruginosa–Mechanisms, epidemiology and evolution

J Botelho, F Grosso, L Peixe - Drug resistance updates, 2019 - Elsevier
Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Bacterial c-di-GMP has a key role in establishing host–microbe symbiosis

N Obeng, A Czerwinski, D Schütz, J Michels… - Nature …, 2023 - nature.com
Most microbes evolve faster than their hosts and should therefore drive evolution of host–
microbe interactions. However, relatively little is known about the characteristics that define …

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

N Zhou, Y Jiang, TR Bergquist, AJ Lee, BZ Kacsoh… - Genome biology, 2019 - Springer
Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an
ongoing, global, community-driven effort to evaluate and improve the computational …

Structure, function and regulation of Pseudomonas aeruginosa porins

S Chevalier, E Bouffartigues, J Bodilis… - FEMS microbiology …, 2017 - academic.oup.com
Pseudomonas aeruginosa is a Gram-negative bacterium belonging to the γ-proteobacteria.
Like other members of the Pseudomonas genus, it is known for its metabolic versatility and …

The Pseudomonas aeruginosa Pan-Genome Provides New Insights on Its Population Structure, Horizontal Gene Transfer, and Pathogenicity

L Freschi, AT Vincent, J Jeukens… - Genome biology and …, 2019 - academic.oup.com
The huge increase in the availability of bacterial genomes led us to a point in which we can
investigate and query pan-genomes, for example, the full set of genes of a given bacterial …

A periplasmic phospholipase that maintains outer membrane lipid asymmetry in Pseudomonas aeruginosa

RL Guest, MJ Lee, W Wang… - Proceedings of the …, 2023 - National Acad Sciences
The outer membrane of Gram-negative bacteria is unique in both structure and function. The
surface-exposed outer leaflet is composed of lipopolysaccharide, while the inner leaflet is …