The cell nucleus plays a key role in cellular mechanoresponses. 3D genome organisation,
gene expression, and cell behaviour, in general, are affected by mechanical force …

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disorder characterized
by progressive replacement of cardiomyocytes by fibrofatty tissue, ventricular dilatation …

Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with
increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates …

The nucleus provides a physical and selective chemical boundary to segregate the genome
from the cytoplasm. The contents of the nucleus are surrounded by the nuclear envelope …

The most common clinical tachyarrhythmia, atrial fibrillation (AF), is present in 1–2% of the
population. Although common risk factors, including hypertension, diabetes, and obesity …

Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of
the heart associated with myocardial tissue loss and fibrosis. These pathologies include …

Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (ie, LMNA
cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in …

Heart failure fundamentally results from loss of cardio myocyte contractility. Developing new
methods that quantify the contractile stress of the human cardiomyocyte would facilitate the …

In this work, we studied an lmna nonsense mutation encoding for the C-terminally truncated
Lamin A/C (LMNA) variant Q517X, which was described in patients affected by a severe …

The interaction between lamin A and the cytoplasmic skeleton plays a key role in
maintaining nuclear mechanical properties. However, the effect of destruction of the …