Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

Recently, we showed that homozygosity for the common 677 (C→ T) mutation in the
methylenetetrahydrofolate reductase (MTHFR) gene, causing thermolability of the enzyme …

Abstract The enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) is involved in
folate metabolism. The MTHFR gene is located on chromosome 1 (1p36. 3), and two …

Background Obstetrical complications such as severe preeclampsia, abruptio placentae,
fetal growth retardation, and stillbirth are associated with intervillous or spiral-artery …

The periconceptional use of folic acid–containing supplements reduces the first occurrence,
as well as the recurrence, of neural tube defects. Women of populations in which adverse …

This review describes current knowledge of the main causes of vitamin B12 and folate
deficiency. The most common explanations for poor vitamin B12 status are a low dietary …

Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically
activate one‐carbon units for biosynthesis. THF‐mediated one‐carbon metabolism is a …

Three topics affecting cobalamin, folate, and homocysteine that have generated interest,
activity, and advances in recent years are discussed. These are:(I) the application of an …

The authors performed a meta-analysis of studies examining the association between
polymorphisms in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, including …