Platelets in wound healing and regenerative medicine

J Etulain - Platelets, 2018 - Taylor & Francis
Although platelets are widely recognized as having a critical role in primary hemostasis and
thrombosis, increasing experimental and clinical evidence identifies these enucleated cells …

Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability

YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

The influence of platelet-derived products on angiogenesis and tissue repair: a concise update

CE Martínez, PC Smith, VA Palma Alvarado - Frontiers in physiology, 2015 - frontiersin.org
Platelet degranulation allows the release of a large amount of soluble mediators, is an
essential step for wound healing initiation, and stimulates clotting, and angiogenesis. The …

Autologous fibrin scaffolds: When platelet-and plasma-derived biomolecules meet fibrin

E Anitua, P Nurden, R Prado, AT Nurden, S Padilla - Biomaterials, 2019 - Elsevier
The healing of vascularized mammalian tissue injuries initiate with hemostasis and clotting
as part of biological defense system leading to the formation of a fibrin clot in which activated …

PRP in wound healing applications

P Oneto, J Etulain - Platelets, 2021 - Taylor & Francis
Platelets play a crucial role in hemostasis, tissue regeneration and host defense. Based on
these settings, platelet-rich plasma (PRP) and its derivatives are therapeutically used to …

Platelet-rich blood derivatives for stem cell-based tissue engineering and regeneration

EA Masoudi, J Ribas, G Kaushik, J Leijten… - Current stem cell …, 2016 - Springer
Platelet-rich blood derivatives have been widely used in different fields of medicine and
stem cell-based tissue engineering. They represent natural cocktails of autologous growth …

Autologous platelet-rich plasma treatment enables pregnancy for a woman in premature menopause

K Sfakianoudis, M Simopoulou, N Nitsos… - Journal of clinical …, 2018 - mdpi.com
This report presents the case of a woman aged 40 who has experienced premature
menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian …

Therapeutic effect of platelet-rich plasma in rat spinal cord injuries

NF Chen, CS Sung, ZH Wen, CH Chen… - Frontiers in …, 2018 - frontiersin.org
Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state,
and harvesting the platelet-rich portion or condensing platelets. Studies have consistently …

Angiogenic properties of 'leukocyte-and platelet-rich fibrin'

J Ratajczak, T Vangansewinkel, P Gervois, G Merckx… - Scientific reports, 2018 - nature.com
Abstract Leukocyte-and Platelet-Rich Fibrin (L-PRF) is an autologous platelet concentrate,
consisting of a fibrin matrix enriched with platelets, leukocytes and a plethora of cytokines …

Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway

L Ao, H Gao, L Jia, S Liu, J Guo, B Liu, Q Dong - Molecular Immunology, 2022 - Elsevier
Matrine (Mat) is an alkaloid of tetracycline quinazine, and previous studies have
demonstrated its specific effect on relieving rheumatoid arthritis (RA). However, the effect of …