Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

▪ Abstract The COP9 signalosome (CSN) is composed of eight distinct subunits and is highly
homologous to the lid sub-complex of the 26S proteasome. CSN was initially defined as a …

The 26 S proteasome mediates degradation of ubiquitin-conjugated proteins. Although
ubiquitin is recycled from proteasome substrates, the molecular basis of deubiquitination at …

COP9 signalosome (CSN) cleaves the ubiquitin-like protein Nedd8 from the Cul1 subunit of
SCF ubiquitin ligases. The Jab1/MPN domain metalloenzyme (JAMM) motif in the …

SCF ubiquitin ligases control various processes by marking regulatory proteins for ubiquitin-
dependent proteolysis. To illuminate how SCF complexes are regulated, we sought proteins …

The COP9 signalosome (CSN) is a conserved protein complex that functions in the ubiquitin–
proteasome pathway. After two decades of research, we now know that the CSN is a multi …

COP9 Signalosome (CSN) is a fascinating protein complex whose biochemical and
physiological functions are only beginning to be understood. It is conserved throughout …

In higher eukaryotic cells, the p53 protein is degraded by the ubiquitin–26S proteasome
system mediated by Mdm2 or the human papilloma virus E6 protein. Here we show that …

By comparing 4,344 protein sequences from fission yeast Schizosaccharomyces pombe
with all available eukaryotic sequences, we identified those genes that are conserved in S …

The fifth component of the COP9 signalosome complex, Jab1/CSN5, directly binds to and
induces specific down-regulation of the cyclin-dependent kinase inhibitor p27 (p27 Kip1) …