Recent aspects of the effects of zinc on human health

CT Chasapis, PSA Ntoupa, CA Spiliopoulou… - Archives of …, 2020 - Springer
Zinc (Zn) is one of the most important essential nutrients of great public health significance. It
is involved in numerous biological functions and it is considered as a multipurpose trace …

Zinc: from biological functions to therapeutic potential

MI Costa, AB Sarmento-Ribeiro… - International Journal of …, 2023 - mdpi.com
The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control
intercellular communication and intracellular events that maintain normal physiological …

Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases

S Choi, X Liu, Z Pan - Acta Pharmacologica Sinica, 2018 - nature.com
Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-
inflammatory functions. The association between zinc deficiency and the development of …

Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis

T Hara, T Takeda, T Takagishi, K Fukue… - The Journal of …, 2017 - Springer
Zinc (Zn) is an essential trace mineral that regulates the expression and activation of
biological molecules such as transcription factors, enzymes, adapters, channels, and growth …

The functions of metallothionein and ZIP and ZnT transporters: an overview and perspective

T Kimura, T Kambe - International journal of molecular sciences, 2016 - mdpi.com
Around 3000 proteins are thought to bind zinc in vivo, which corresponds to~ 10% of the
human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component …

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

T Bertero, WM Oldham, KA Cottrill… - The Journal of …, 2016 - Am Soc Clin Investig
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the …

Roles of zinc signaling in the immune system

S Hojyo, T Fukada - Journal of immunology research, 2016 - Wiley Online Library
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth,
differentiation, and survival. Zn deficiency depresses both innate and adaptive immune …

The emerging role of zinc transporters in cellular homeostasis and cancer

E Bafaro, Y Liu, Y Xu, RE Dempski - Signal transduction and targeted …, 2017 - nature.com
Zinc is an essential micronutrient that plays a role in the structural or enzymatic functions of
many cellular proteins. Cellular zinc homeostasis involves the opposing action of two …

Regulation of cell proliferation by hypoxia-inducible factors

ME Hubbi, GL Semenza - American Journal of Physiology …, 2015 - journals.physiology.org
Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

The role of hypoxia-inducible factors in cardiovascular diseases

B Yu, X Wang, Y Song, G Xie, S Jiao, L Shi… - Pharmacology & …, 2022 - Elsevier
Cardiovascular diseases are the leading cause of death worldwide. During the development
of cardiovascular diseases, hypoxia plays a crucial role. Hypoxia-inducible factors (HIFs) are …