Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

Aging of the central nervous system (CNS) is one of the major risk factors for the
development of neurodegenerative pathologies such as Parkinson's disease (PD) and …

Activation of the inflammasome is implicated in the pathogenesis of an increasing number of
inflammatory diseases, including Alzheimer's disease (AD). Research reporting …

Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …

Among the changes that typify Alzheimer's disease (AD) are neuroinflammation and
microglial activation, amyloid deposition perhaps resulting from compromised microglial …

Microglial activation and neuroinflammatory changes are characteristic of the aged brain
and contribute to age-related cognitive impairment. Exercise improves cognitive function in …

The relationship between systemic immunity and neuroinflammation is widely recognised.
Infiltration of peripheral immune cells to the CNS during certain chronic inflammatory states …

Background Microglia are multifunctional cells that are primarily neuroprotective and a
deficit in their functional integrity is likely to be a contributory factor in the deteriorating …

Neuroinflammation and activation of innate immunity are early events in neurodegenerative
diseases including Alzheimer's disease (AD). Recently, a rare mutation in the gene …

Microglia serve key functions in the central nervous system (CNS), participating in the
establishment and regulation of synapses and the neuronal network, and regulating activity …