NO and HNO donors, nitrones, and nitroxides: Past, present, and future

C Oliveira, S Benfeito, C Fernandes… - Medicinal research …, 2018 - Wiley Online Library
The biological effects attributed to nitric oxide (• NO) and nitroxyl (HNO) have been
extensively studied, propelling their array of putative clinical applications beyond …

Methods for reactive oxygen species (ROS) detection in aqueous environments

JM Burns, WJ Cooper, JL Ferry, DW King, BP DiMento… - Aquatic sciences, 2012 - Springer
This review summarizes direct and indirect analytical methods for the detection and
quantification of the reactive oxygen species (ROS): 1 O 2, O 2·−/HOO·, H 2 O 2, HO·, and …

Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics

FA Villamena, A Das, KM Nash - Future medicinal chemistry, 2012 - Taylor & Francis
Nitrone therapeutics has been employed in the treatment of oxidative stress-related
diseases such as neurodegeneration, cardiovascular disease and cancer. The nitrone …

Use of rapid-scan EPR to improve detection sensitivity for spin-trapped radicals

DG Mitchell, GM Rosen, M Tseitlin, B Symmes… - Biophysical journal, 2013 - cell.com
The short lifetime of superoxide and the low rates of formation expected in vivo make
detection by standard continuous wave (CW) electron paramagnetic resonance (EPR) …

β-Irradiation in the presence of 1, 3-dialkylimidazolium ionic liquids causes covalent cellulose derivatization with simultaneous nitrogen incorporation

P Jusner, I Sulaeva, S Schiehser, K Potthast, A Tischer… - Cellulose, 2023 - Springer
Abstract β-Irradiation (“e-beaming”) as well as swelling in ionic liquids, each process by
itself, are common pretreatments in biorefinery scenarios. A combination of both, such as …

Reactivity of superoxide radical anion with cyclic nitrones: role of intramolecular H-bond and electrostatic effects

FA Villamena, S Xia, JK Merle… - Journal of the …, 2007 - ACS Publications
Limitations exist among the commonly used cyclic nitrone spin traps for biological free
radical detection using electron paramagnetic resonance (EPR) spectroscopy. The design of …

Esters of 5-Carboxyl-5-methyl-1-pyrroline N-Oxide:  A Family of Spin Traps for Superoxide

P Tsai, K Ichikawa, C Mailer, S Pou… - The Journal of …, 2003 - ACS Publications
Apparent rate constants, at acidic pH and neutral pH for the reaction of a family of ester-
containing 5-carboxyl-5-methyl-1-pyrroline N-oxides with superoxide (O2•-) were estimated …

Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO). 1. The Thermodynamics of Formation and Its Acidity

FA Villamena, JK Merle, CM Hadad… - The Journal of Physical …, 2005 - ACS Publications
The nitrone 5, 5-dimethyl-1-pyrroline N-oxide (DMPO) has been the most widely used spin
trap for the detection of transient free radicals in chemical, biological, and biomedical …

Superoxide Radical Anion Adduct of 5,5-Dimethyl-1-pyrroline N-Oxide (DMPO). 2. The Thermodynamics of Decay and EPR Spectral Properties

FA Villamena, JK Merle, CM Hadad… - The Journal of Physical …, 2005 - ACS Publications
The formation of the superoxide radical anion (O2•-) adduct of the nitrone 5, 5-dimethyl-1-
pyrroline N-oxide (DMPO) as detected by electron paramagnetic resonance (EPR) …

A new class of ligands for aqueous, lanthanide-catalyzed, enantioselective mukaiyama aldol reactions

Y Mei, P Dissanayake, MJ Allen - Journal of the American …, 2010 - ACS Publications
The development of aqueous methods for generating enantiopure β-hydroxy carbonyl
compounds is an important goal because these subunits compose many bioactive …