Conventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue
pathology. However, this technique is associated with a number of limitations, including high …

Tissues and organs are composed of distinct cell types that must operate in concert to
perform physiological functions. Efforts to create high-dimensional biomarker catalogs of …

A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of
identifying the precise boundary of every cell in an image. To address this problem we …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by notorious resistance to
current therapies attributed to inherent tumor heterogeneity and highly desmoplastic and …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is
known about the interplay between responses and its impact on T cell function and tumor …

Imaging mass cytometry (IMC) is a highly multiplexed, antibody-based imaging method that
captures heterogeneous spatial protein expression patterns at subcellular resolution. Here …

Multiplexed imaging and spatial transcriptomics enable highly resolved spatial
characterization of cellular phenotypes, but still largely depend on laborious manual …

A cell's phenotype is the culmination of several cellular processes through a complex
network of molecular interactions that ultimately result in a unique morphological signature …

Imaging mass spectrometry has become a mature molecular mapping technology that is
used for molecular discovery in many medical and biological systems. While powerful by …