Polymeric nitric oxide delivery nanoplatforms for treating cancer, cardiovascular diseases, and infection
The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated
the unique advances in biomedical applications due to its prominent role in regulating …
the unique advances in biomedical applications due to its prominent role in regulating …
Intraflagellar transport proteins as regulators of primary cilia length
Primary cilia are small, antenna-like organelles that detect and transduce chemical and
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …
mechanical cues in the extracellular environment, regulating cell behavior and, in turn …
[HTML][HTML] Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: in physiology and in disease states
N Tran, T Garcia, M Aniqa, S Ali, A Ally… - American journal of …, 2022 - ncbi.nlm.nih.gov
Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
An organelle‐specific nanozyme for diabetes care in genetically or diet‐induced models
Y Zhou, C Liu, Y Yu, M Yin, J Sun, J Huang… - Advanced …, 2020 - Wiley Online Library
The development of nanozymes has made active impact in diagnosis and therapeutics.
However, understanding of the full effects of these nanozymes on biochemical pathways …
However, understanding of the full effects of these nanozymes on biochemical pathways …
Nanosystems in cardiovascular medicine: advancements, applications, and future perspectives
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality globally.
Despite significant advancements in the development of pharmacological therapies, the …
Despite significant advancements in the development of pharmacological therapies, the …
Hedgehog and Gpr161: Regulating cAMP signaling in the primary cilium
P Tschaikner, F Enzler, O Torres-Quesada, P Aanstad… - Cells, 2020 - mdpi.com
Compartmentalization of diverse types of signaling molecules contributes to the precise
coordination of signal propagation. The primary cilium fulfills this function by acting as a …
coordination of signal propagation. The primary cilium fulfills this function by acting as a …
Patterns of cilia gene dysregulations in major psychiatric disorders
Primary cilia function as cells' antennas to detect and transduce external stimuli and play
crucial roles in cell signaling and communication. The vast majority of cilia genes that are …
crucial roles in cell signaling and communication. The vast majority of cilia genes that are …
Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses
Although rapamycin is a very effective drug for rodents with polycystic kidney disease (PKD),
it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off …
it is not encouraging in the clinical trials due to the suboptimal dosages compelled by the off …
Sensory primary cilium is a responsive cAMP microdomain in renal epithelia
Primary cilia are hair-like cellular extensions that sense microenvironmental signals
surrounding cells. The role of adenylyl cyclases in ciliary function has been of interest …
surrounding cells. The role of adenylyl cyclases in ciliary function has been of interest …
Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2
Abstract The coronavirus disease-19 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV2) has taken the world by surprise. To date, a …
syndrome coronavirus 2 (SARS-CoV2) has taken the world by surprise. To date, a …