Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last
decade, major progress has been made to further understand caspase structure and …

Abstract CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of
CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation …

Caspases belong to a family of highly conserved aspartate-specific cysteine proteases and
are members of the interleukin-1β-converting enzyme family, present in multicellular …

The molecular regulation of the recruitment of initial signaling complexes at the TNF-R1 is
poorly defined. We demonstrate here that within minutes internalized TNF-R1 (TNF …

Apoptosis is an important physiological process crucially involved in development and
homeostasis of multicellular organisms. Although the major signaling pathways have been …

Mathematical modeling is required for understanding the complex behavior of large signal
transduction networks. Previous attempts to model signal transduction pathways were often …

c-FLIPs (c-FLICE inhibitory proteins) play an essential role in regulation of death receptor-
induced apoptosis. Multiple splice variants of c-FLIP have been described on the mRNA …

Differentiation of human placental villous trophoblast includes syncytial fusion of
cytotrophoblast forming syncytiotrophoblast. Early stages of the apoptosis cascade were …

This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO‐1) in
some situations results in cell death and in others leads to the activation of NF‐κB. We …