Constitutive heterochromatin formation and transcription in mammals
N Saksouk, E Simboeck, J Déjardin - Epigenetics & chromatin, 2015 - Springer
Constitutive heterochromatin, mainly formed at the gene-poor regions of pericentromeres, is
believed to ensure a condensed and transcriptionally inert chromatin conformation …
believed to ensure a condensed and transcriptionally inert chromatin conformation …
Variants of core histones and their roles in cell fate decisions, development and cancer
M Buschbeck, SB Hake - Nature reviews Molecular cell biology, 2017 - nature.com
Histone variants endow chromatin with unique properties and show a specific genomic
distribution that is regulated by specific deposition and removal machineries. These variants …
distribution that is regulated by specific deposition and removal machineries. These variants …
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
The mechanisms underlying gene repression and silencers are poorly understood. Here we
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters …
Functions of lncRNA HOTAIR in lung cancer
G Loewen, J Jayawickramarajah, Y Zhuo… - Journal of hematology & …, 2014 - Springer
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes.
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …
lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through …
Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
R Kogo, T Shimamura, K Mimori, K Kawahara, S Imoto… - Cancer research, 2011 - AACR
The functional impact of recently discovered long noncoding RNAs (ncRNAs) in human
cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox …
cancer remains to be clarified. One long ncRNA which has attracted attention is the Hox …
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
SK Knutson, TJ Wigle, NM Warholic… - Nature chemical …, 2012 - nature.com
EZH2 catalyzes trimethylation of histone H3 lysine 27 (H3K27). Point mutations of EZH2 at
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …
Tyr641 and Ala677 occur in subpopulations of non-Hodgkin's lymphoma, where they drive …
Epigenetics and colorectal cancer
VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Follicular lymphoma (FL) and the GCB subtype of diffuse large B-cell lymphoma (DLBCL)
derive from germinal center B cells. Targeted resequencing studies have revealed mutations …
derive from germinal center B cells. Targeted resequencing studies have revealed mutations …
Genetic alterations and their clinical implications in DLBCL
Y Miao, LJ Medeiros, Y Li, J Li, KH Young - Nature reviews Clinical …, 2019 - nature.com
Diffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm with
variations in gene expression profiles and genetic alterations, which lead to substantial …
variations in gene expression profiles and genetic alterations, which lead to substantial …
Diffuse large B-cell lymphoma—treatment approaches in the molecular era
Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell non-Hodgkin lymphoma that
affects patients of all ages with a wide range of clinical presentations. Although DLBCL is …
affects patients of all ages with a wide range of clinical presentations. Although DLBCL is …