Regulation, signaling, and physiological functions of G-proteins

V Syrovatkina, KO Alegre, R Dey, XY Huang - Journal of molecular biology, 2016 - Elsevier
Heterotrimeric guanine-nucleotide-binding regulatory proteins (G-proteins) mainly relay the
information from G-protein-coupled receptors (GPCRs) on the plasma membrane to the …

Update on melatonin receptors: IUPHAR Review 20

R Jockers, P Delagrange… - British journal of …, 2016 - Wiley Online Library
Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR
superfamily. In mammals, two melatonin receptor subtypes exist‐MT1 and MT2‐encoded by …

[HTML][HTML] A global map of G protein signaling regulation by RGS proteins

I Masuho, S Balaji, BS Muntean, NK Skamangas… - Cell, 2020 - cell.com
The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …

Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets

AJ Kimple, DE Bosch, PM Giguere… - Pharmacological reviews, 2011 - ASPET
Because G-protein coupled receptors (GPCRs) continue to represent excellent targets for
the discovery and development of small-molecule therapeutics, it is posited that additional …

G protein-coupled receptor-G protein interactions: a single-molecule perspective

D Calebiro, Z Koszegi, Y Lanoiselée… - Physiological …, 2021 - journals.physiology.org
G protein-coupled receptors (GPCRs) regulate many cellular and physiological processes,
responding to a diverse range of extracellular stimuli including hormones, neurotransmitters …

Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing

Z Zhao, D Zhang, F Yang, M Xu, S Zhao, T Pan, C Liu… - Cell research, 2022 - nature.com
The differences in size and function between primate and rodent brains, and the association
of disturbed excitatory/inhibitory balance with many neurodevelopmental disorders highlight …

Molecular architecture of the Gαi-bound TRPC5 ion channel

J Won, J Kim, H Jeong, J Kim, S Feng, B Jeong… - Nature …, 2023 - nature.com
G-protein coupled receptors (GPCRs) and ion channels serve as key molecular switches
through which extracellular stimuli are transformed into intracellular effects, and it has long …

Invited review: Activation of G proteins by GTP and the mechanism of Gα‐catalyzed GTP hydrolysis

SR Sprang - Biopolymers, 2016 - Wiley Online Library
This review addresses the regulatory consequences of the binding of GTP to the alpha
subunits (Gα) of heterotrimeric G proteins, the reaction mechanism of GTP hydrolysis …

[HTML][HTML] Identification of a five-gene signature of the RGS gene family with prognostic value in ovarian cancer

Y Hu, M Zheng, S Wang, L Gao, R Gou, O Liu, H Dong… - Genomics, 2021 - Elsevier
The RGS (regulator of G protein signaling) gene family, which includes negative regulators
of G protein-coupled receptors, comprises important drug targets for malignant tumors. It is …

Grading the commercial optical biosensor literature—Class of 2008:'The Mighty Binders'

RL Rich, DG Myszka - Journal of Molecular Recognition: An …, 2010 - Wiley Online Library
Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …