Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

In the tumor microenvironment (TME), tumor cells are constantly evolving to reduce
neoantigen generation and the mutational burden to escape the anti-tumor response. This …

The etiology of migraine pain involves sensitized meningeal afferents that densely innervate
the dural vasculature. These afferents, with their cell bodies located in the trigeminal …

Immune checkpoint inhibitors (ICIs) are starting to transform the treatment for patients with
advanced cancer. The extensive application of these antibodies for various cancer obtains …

Solitary chemosensory cells (SCCs) of the nasal cavity are specialized epithelial
chemosensors that respond to irritants through the canonical taste transduction cascade …

Background & Aims IgG subclass 4–related disease (IgG4-RD) is characterized by
increased serum levels of IgG4 and infiltration of biliary, pancreatic, and other tissues by …

Mast cells (MCs) are granulated, immune cells of the myeloid lineage that are present in
connective tissues. Apart from their classical role in allergies, MCs also mediate various …

Mast cells are tissue-resident immune cells that release immuno-modulators, chemo-
attractants, vasoactive compounds, neuropeptides and growth factors in response to …

Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …