The innate immune system constitutes the first line of defense against invading microbial
pathogens and relies on a large family of pattern recognition receptors (PRRs), which detect …

Group B Streptococcus (GBS) colonizes the gastrointestinal and vaginal epithelium of a
significant percentage of healthy women, with potential for ascending intrauterine infection …

It is known that host cells can produce type I IFNs (IFN-αβ) after exposure to conserved
bacterial products, but the functional consequences of such responses on the outcome of …

Group B Streptococcus commonly colonises healthy adults without symptoms, yet under
certain circumstances displays the ability to invade host tissues, evade immune detection …

Most Toll‐like‐receptors (TLR s) and interleukin‐1 receptors (IL‐1 R s) signal via myeloid
differentiation primary response 88 (M y D 88) and interleukin‐1 receptor‐associated kinase …

Group B streptococci (GBSs) are the leading cause of neonatal meningitis. GBSs enter the
CNS by penetrating the blood-brain barrier (BBB), which consists of specialized human …

Streptococcus suis, an important swine and human pathogen, causes septic shock and
meningitis. The pathogenesis of both systemic and CNS infections caused by S. suis is …

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where
it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive …

Abstract Group B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and
meningitis in neonates and adults with predisposing conditions. We tested the hypothesis …

Toll-like receptors (TLRs) are pattern recognition receptors (PRR) that recognize molecular
structures on pathogens and activate host defenses. Although much is known about specific …