Characterization of lipid–protein interactions and lipid-mediated modulation of membrane protein function through molecular simulation
The cellular membrane constitutes one of the most fundamental compartments of a living
cell, where key processes such as selective transport of material and exchange of …
cell, where key processes such as selective transport of material and exchange of …
[HTML][HTML] Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia in the elderly, and affects
millions of people worldwide. As the number of AD cases continues to increase in both …
millions of people worldwide. As the number of AD cases continues to increase in both …
A hairpin motif in the amyloid-β peptide is important for formation of disease-related oligomers
The amyloid-β (Aβ) peptide is associated with the development of Alzheimer's disease and
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …
is known to form highly neurotoxic prefibrillar oligomeric aggregates, which are difficult to …
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
Alzheimer's disease is a neurodegenerative disorder associated with the aberrant
aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol …
aggregation of the amyloid-β peptide. Although increasing evidence implicates cholesterol …
[HTML][HTML] Glaucoma: the retina and beyond
BM Davis, L Crawley, M Pahlitzsch, F Javaid… - Acta …, 2016 - Springer
Over 60 million people worldwide are diagnosed with glaucomatous optic neuropathy,
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
which is estimated to be responsible for 8.4 million cases of irreversible blindness globally …
[HTML][HTML] Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
B Kim, EL Feldman - Experimental & molecular medicine, 2015 - nature.com
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity,
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …
Effects of in vivo conditions on amyloid aggregation
One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …
govern protein misfolding and aggregation, which is a highly complex process that is …
[HTML][HTML] ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models
Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation,
however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA …
however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA …
Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration
E Rojas‐Gutierrez, G Muñoz‐Arenas, S Treviño… - Synapse, 2017 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia and one of the most
important causes of morbidity and mortality among the aging population. AD diagnosis is …
important causes of morbidity and mortality among the aging population. AD diagnosis is …
[HTML][HTML] Alzheimer's disease as a membrane disorder: spatial cross-talk among beta-amyloid peptides, nicotinic acetylcholine receptors and lipid rafts
C Fabiani, SS Antollini - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …