Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …

The progression of cancer is not only about the tumor cell itself, but also about other
involved players including cancer cell recruited immune cells, their released pro …

Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …

Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …

Introduction Systemic inflammation is associated with prognosis in solid tumors. The
neutrophil-to-lymphocyte ratio (NLR) is a marker for the general immune response to various …

Tumors consist of cancer cells and a network of non-cancerous stroma. Cancer-associated
fibroblasts (CAF) are known to support tumorigenesis, and are emerging as immune …

Recent findings have uncovered novel fascinating aspects of the biology of neutrophils,
which ultimately attribute to these cells a broader role in inflammation and immunity. One …