Anti-neuroinflammatory potential of polyphenols by inhibiting NF-κB to halt Alzheimer's disease

MS Uddin, S Hasana, J Ahmad… - Current …, 2021 - ingentaconnect.com
Alzheimer's disease (AD) is an irrevocable chronic brain disorder featured by neuronal loss,
microglial accumulation, and progressive cognitive impairment. The proper pathophysiology …

Natural small molecules targeting NF-κB signaling in glioblastoma

MS Uddin, MT Kabir, AA Mamun, MS Sarwar… - Frontiers in …, 2021 - frontiersin.org
Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate
various cellular activities, including propagation, differentiation, motility, and survival …

Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network

Y Sun, W Guo, Y Guo, Z Lin, D Wang, Q Guo… - Food and Chemical …, 2022 - Elsevier
Prostate cancer (PCa) cells exploit cellular metabolic reprogramming as their survival
advantage, especially aberrant lipid signaling and metabolism. Although recent studies …

Identification of Antitumor Active Constituents in Polygonatum sibiricum Flower by UPLC-Q-TOF-MSE and Network Pharmacology

Z Huang, X Du, C Ma, R Zhang, W Gong, F Liu - ACS omega, 2020 - ACS Publications
We aimed to investigate the material basis and mechanisms underlying the antitumor activity
of Polygonatum sibiricum flower by ultra-performance liquid chromatography quadrupole …

Exploring the role of senescence inducers and senotherapeutics as targets for anticancer natural products

A Al Mamun, MA Sufian, MS Uddin… - European journal of …, 2022 - Elsevier
During the last few decades, cancer has remained one of the deadliest diseases that
endanger human health, emphasizing urgent drug discovery. Cellular senescence has …

Wogonin, as a potent anticancer compound: From chemistry to cellular interactions

HS Tuli, P Rath, A Chauhan… - Experimental …, 2023 - journals.sagepub.com
Chinese native medicine Scutellaria baicalensis Georgi, also referred to as Chinese
skullcap or Huang-Qin, is frequently used to treat cancer, viral infections, and seizures. This …

Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression

Z Ni, H Ma, X Li, L Zou, Z Liu, X Wang… - Environmental …, 2023 - Wiley Online Library
Abstract Benzo [a] pyrene (BaP) is a common air pollutant that has been reported to cause
oxidative stress and carcinogenesis. Wogonin, a flavonoid compound extracted from the …

Autophagy Induction by Scutellaria Flavones in Cancer: Recent Advances

HS Tuli, S Bhushan, A Kumar, P Aggarwal, K Sak… - Pharmaceuticals, 2023 - mdpi.com
In parallel with a steady rise in cancer incidence worldwide, the scientific community is
increasingly focused on finding novel, safer and more efficient modalities for managing this …

FV-429 induces apoptosis by regulating nuclear translocation of PKM2 in pancreatic cancer cells

X Jin, Q Min, D Wang, Y Wang, G Li, Z Wang, Y Guo… - Heliyon, 2024 - cell.com
Of all malignancies, pancreatic ductal adenocarcinoma (PDAC), constituting 90% of
pancreatic cancers, has the worst prognosis. Glycolysis is overactive in PDAC patients and …

[HTML][HTML] Telomere length: biological marker of cellular vitality, aging, and health-disease process

MZ Teixeira - Revista da Associação Médica Brasileira, 2021 - SciELO Brasil
The aging process occurs due to the decline of vital physiological functions and adaptability
of the body, being influenced by genetics and lifestyle. With advances in genetics, biological …