The need for better antifungal therapy is commonly accepted in view of the high mortality
rates associated with systemic infections, the low number of available antifungal classes …

Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal
therapeutics include polyenes, azoles, and echinocandins. However, even in the setting of …

Background: Paracoccidioidomycosis (PCM) is a chronic disease that causes sequelae and
requires prolonged treatment; therefore, new therapeutic approaches are necessary. In view …

About half of the world's population and 80% of the world's biodiversity can be found in the
tropics. Many diseases are specific to the tropics, with at least 41 diseases caused by …

Fungal infections have aroused much interest over the last years because of their
involvement in several human diseases. Immunocompromission due to transplant-related …

Vaccination is one of the greatest public health achievements in the past century, protecting
and improving the quality of life of the population worldwide. However, a safe and effective …

Protective immunity against Paracoccidioides consists of a stepwise activation of numerous
effector mechanisms that comprise many cellular and soluble components. At the initial …

Introduction Fungal infections are caused by a broad range of pathogenic fungi that are
found worldwide with different geographic distributions, incidences, and mortality rates …

Dendritic cells (DCs) are essential players in the activation of T cells and in the development
of adaptive immune response towards invading pathogens. Upon antigen (Ag) recognition …

Paracoccidioidomycosis (PCM) is an endemic mycosis in Latin American caused by the
thermodimorphic fungi of the genus Paracoccidioides spp. Notably, a Th1 immune response …