Biological basis for syphilis

RE LaFond, SA Lukehart - Clinical microbiology reviews, 2006 - Am Soc Microbiol
Syphilis is a chronic sexually transmitted disease caused by Treponema pallidum subsp.
pallidum. Clinical manifestations separate the disease into stages; late stages of disease are …

The endemic treponematoses

L Giacani, SA Lukehart - Clinical microbiology reviews, 2014 - Am Soc Microbiol
The agents of human treponematoses include four closely related members of the genus
Treponema: three subspecies of Treponema pallidum plus Treponema carateum. T …

On the origin of the treponematoses: a phylogenetic approach

KN Harper, PS Ocampo, BM Steiner… - PLoS neglected …, 2008 - journals.plos.org
Background Since the first recorded epidemic of syphilis in 1495, controversy has
surrounded the origins of the bacterium Treponema pallidum subsp. pallidum and its …

[HTML][HTML] The endemic treponematoses

GM Antal, SA Lukehart, AZ Meheus - Microbes and Infection, 2002 - Elsevier
Treponemal diseases comprise venereal syphilis (Treponema pallidum subsp. pallidum)
and the endemic (non-venereal) treponematoses, ie yaws (T. pallidum subsp. pertenue) …

Yaws

O Mitjà, K Asiedu, D Mabey - The Lancet, 2013 - thelancet.com
Yaws is an infectious disease caused by Treponema pallidum pertenue—a bacterium that
closely resembles the causative agent of syphilis—and is spread by skin-to-skin contact in …

The emerging physiological roles of the glycerophosphodiesterase family

D Corda, MG Mosca, N Ohshima, L Grauso… - The FEBS …, 2014 - Wiley Online Library
The glycerophosphodiester phosphodiesterases are evolutionarily conserved proteins that
have been linked to several patho/physiological functions, comprising bacterial …

[HTML][HTML] Genetic diversity in Treponema pallidum: implications for pathogenesis, evolution and molecular diagnostics of syphilis and yaws

D Šmajs, SJ Norris, GM Weinstock - Infection, Genetics and Evolution, 2012 - Elsevier
Pathogenic uncultivable treponemes, similar to syphilis-causing Treponema pallidum
subspecies pallidum, include T. pallidum ssp. pertenue, T. pallidum ssp. endemicum and …

Opsonic Potential, Protective Capacity, and Sequence Conservation of the Treponema pallidum subspecies pallidum Tp92

CE Cameron, SA Lukehart, C Castro… - The Journal of …, 2000 - academic.oup.com
By means of a differential screening technique, a 92-kDa antigen, designated Tp92, was
identified from Treponema pallidum subspecies pallidum. This protein is similar in sequence …

Syphilis at the crossroad of phylogenetics and paleopathology

FL De Melo, JCM De Mello, AM Fraga… - PLoS neglected …, 2010 - journals.plos.org
The origin of syphilis is still controversial. Different research avenues explore its fascinating
history. Here we employed a new integrative approach, where paleopathology and …

Fine Analysis of Genetic Diversity of the tpr Gene Family among Treponemal Species, Subspecies and Strains

A Centurion-Lara, L Giacani, C Godornes… - PLoS neglected …, 2013 - journals.plos.org
Background The pathogenic non-cultivable treponemes include three subspecies of
Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and …