Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

The goal of this review article is to provide a conceptual based summary of how heritability
estimates for complex traits such as obesity are determined and to explore the future …

Epigenetics increasingly occupies a pivotal position in our understanding of inheritance,
natural selection and, perhaps, even evolution. A survey of the PubMed database, however …

The incidence of neurodevelopmental and neurodegenerative diseases worldwide has
dramatically increased over the last decades. Although the aetiology remains uncertain …

Several studies have described phenotypic changes in the offspring of mice exposed to a
variety of environmental factors, including diet, toxins, and stress; however, the molecular …

In mammals, early adverse experiences, including mother–pup interactions, shape the
response of an individual to chronic stress or to stress-related diseases during adult life. This …

Despite significant overlaps in mission, the fields of environmental health sciences and
aging biology are just beginning to intersect. It is increasingly clear that genetics alone does …

Lines of evidence have demonstrated that early-life malnutrition is highly correlated with
neurodevelopment and adulthood neuropsychiatric disorders, while some findings are …

Background DNA methylation patterns are initiated by de novo DNA methyltransferases
DNMT3a/3b adding methyl groups to CG dinucleotides in the hypomethylated genome of …