Randall's plaque and calcium oxalate stone formation: role for immunity and inflammation

SR Khan, BK Canales… - Nature Reviews …, 2021 - nature.com
Idiopathic calcium oxalate (CaOx) stones often develop attached to Randall's plaque
present on kidney papillary surfaces. Similar to the plaques formed during vascular …

New strategies to improve clinical outcomes for diabetic kidney disease

T Forst, C Mathieu, F Giorgino, DC Wheeler… - Bmc Medicine, 2022 - Springer
Background Diabetic kidney disease (DKD), the most common cause of kidney failure and
end-stage kidney disease worldwide, will develop in almost half of all people with type 2 …

Prediction of type 2 diabetes mellitus using hematological factors based on machine learning approaches: a cohort study analysis

A Mansoori, T Sahranavard, ZS Hosseini, SS Soflaei… - Scientific Reports, 2023 - nature.com
Abstract Type 2 Diabetes Mellitus (T2DM) is a significant public health problem globally. The
diagnosis and management of diabetes are critical to reduce the diabetes complications …

Patient stratification for determining optimal second-line and third-line therapy for type 2 diabetes: the TriMaster study

BM Shields, JM Dennis, CD Angwin, F Warren… - Nature medicine, 2023 - nature.com
Precision medicine aims to treat an individual based on their clinical characteristics. A
differential drug response, critical to using these features for therapy selection, has never …

Nanohybrid double network hydrogels based on a platinum nanozyme composite for antimicrobial and diabetic wound healing

Z Zhou, X Mei, K Hu, M Ma, Y Zhang - ACS applied materials & …, 2023 - ACS Publications
Along with hypoxia, severe bacterial infection, and abnormal pH, continuous inflammatory
response hinders diabetic wounds from healing. It leads to the accumulation of large …

[HTML][HTML] Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

N Apostolova, F Iannantuoni, A Gruevska, J Muntane… - Redox biology, 2020 - Elsevier
Abstract Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …

Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996–2016

B Carstensen, PF Rønn, ME Jørgensen - BMJ Open Diabetes …, 2020 - drc.bmj.com
Introduction The objective of this study was to give an overview of prevalence, incidence and
mortality of type 1 (T1D) and type 2 diabetes (T2D) in Denmark, and their temporal trends …

Macrovasculature and microvasculature at the crossroads between type 2 diabetes mellitus and hypertension

RE Climie, TT van Sloten, RM Bruno, S Taddei… - …, 2019 - Am Heart Assoc
Climie et al Macrovasculature and Microvasculature in HTN and T2D 1139 million global
disability-adjusted life years, an increase of 11.7% from 2005. 9 Because hypertension …

Closed-loop diabetes minipatch based on a biosensor and an electroosmotic pump on hollow biodegradable microneedles

X Luo, Q Yu, Y Liu, W Gai, L Ye, L Yang, Y Cui - ACS sensors, 2022 - ACS Publications
Developing a miniaturized, low-cost, and smart closed-loop system for diabetes could
significantly improve life quality and benefit millions of people. Conventional closed-loop …

Understanding diabetes heterogeneity: key steps towards precision medicine in diabetes

RD Leslie, RCW Ma, PW Franks, KJ Nadeau… - The Lancet Diabetes & …, 2023 - thelancet.com
Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single
blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful …