DNA cruciforms play an important role in the regulation of natural processes involving DNA.
These structures are formed by inverted repeats, and their stability is enhanced by DNA …

Homologous recombination (HR) performs crucial functions including DNA repair,
segregation of homologous chromosomes, propagation of genetic diversity, and …

Bloom's syndrome (BS) is an autosomal recessive disorder characterized by a strong cancer
predisposition. The defining feature of BS is extreme genome instability. The gene mutated …

RAD51 is a key protein of homologous recombination that plays a critical role in the repair of
DNA double-strand breaks (DSB) and interstrand cross-links (ICL). To better understand the …

The displacement loop (D loop) is the product of homology search and DNA strand invasion,
constituting a central intermediate in homologous recombination (HR). In eukaryotes, the …

Homologous recombination is a central pathway to maintain genomic stability and is
involved in the repair of DNA damage and replication fork support, as well as accurate …

Homologous recombination (HR) uses a homologous template to accurately repair DNA
double-strand breaks and stalled replication forks to maintain genome stability. During …

DNA lesions cause stalling of DNA replication forks, which can be lethal for the cell.
Homologous recombination (HR) plays an important role in DNA lesion bypass. It is thought …

In response to DNA damage, the Fanconi anemia (FA) core complex functions as a
signaling machine for monoubiquitination of FANCD2 and FANCI. It remains unclear …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …