[HTML][HTML] Using ncRNAs as tools in Cancer diagnosis and treatment—the way towards personalized medicine to improve patients' health

R Piergentili, G Basile, C Nocella, R Carnevale… - International journal of …, 2022 - mdpi.com
Although the first discovery of a non-coding RNA (ncRNA) dates back to 1958, only in recent
years has the complexity of the transcriptome started to be elucidated. However, its …

Human endogenous retroviruses in cancer: Oncogenesis mechanisms and clinical implications

K Kitsou, P Lagiou, G Magiorkinis - Journal of Medical Virology, 2023 - Wiley Online Library
Abstract Human Endogenous Retroviruses (HERVs) are viral sequences integrated into the
human genome, resulting from the infection of human germ‐line cells by ancient exogenous …

[HTML][HTML] Advances in immunotherapy for MMR proficient colorectal cancer

H Lote, N Starling, R Pihlak, M Gerlinger - Cancer treatment reviews, 2022 - Elsevier
Survival in mismatch-repair proficient (MMRp) metastatic colorectal cancer (mCRC) remains
poor and chemotherapy is the mainstay of treatment. Immunotherapy has demonstrated …

[HTML][HTML] Ancient adversary–HERV-K (HML-2) in cancer

E Dervan, DD Bhattacharyya, JD McAuliffe… - Frontiers in …, 2021 - frontiersin.org
Human endogenous retroviruses (HERV), ancient integrations of exogenous viruses, make
up 8% of our genome. Long thought of as mere vestigial genetic elements, evidence is now …

[HTML][HTML] Telemedicine, telepsychiatry and COVID-19 pandemic: future prospects for global health

S Marinelli, G Basile, S Zaami - Healthcare, 2022 - mdpi.com
There is no denying that demand for telemedicine and telepsychiatry services has been on
the rise, as the COVID-19 pandemic engulfed the world and upset the daily lives and …

[HTML][HTML] The role of HERV-K in cancer stemness

SR Rivas, MJM Valdez, V Govindarajan, D Seetharam… - Viruses, 2022 - mdpi.com
Human endogenous retrovirus-K (HERV-K) is the most recently integrated retrovirus in the
human genome, with implications for multiple disorders, including cancer. Although typically …

[HTML][HTML] Anti-HERV-K drugs and vaccines, possible therapies against tumors

S Hosseiniporgham, LA Sechi - Vaccines, 2023 - mdpi.com
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been
found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer …

[HTML][HTML] Human Endogenous Retrovirus-K (HML-2)-Related Genetic Variation: Human Genome Diversity and Disease

W Shin, S Mun, K Han - Genes, 2023 - mdpi.com
Human endogenous retroviruses (HERVs) comprise a significant portion of the human
genome, making up roughly 8%, a notable comparison to the 2–3% represented by coding …

[HTML][HTML] Transcriptional and reverse transcriptional regulation of host genes by human endogenous retroviruses in cancers

M Zhang, S Zheng, JQ Liang - Frontiers in microbiology, 2022 - frontiersin.org
Human endogenous retroviruses (HERVs) originated from ancient retroviral infections of
germline cells millions of years ago and have evolved as part of the host genome. HERVs …

[HTML][HTML] Identification of differentially expressed HERV-K (HML-2) loci in colorectal cancer

Q Kang, X Guo, T Li, C Yang, J Han, L Jia… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer is one of the malignant tumors with the highest mortality rate in the world.
Survival rates vary significantly among patients at various stages of the disease. A biomarker …