[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

The intrarenal renin-angiotensin system: from physiology to the pathobiology of hypertension and kidney disease

H Kobori, M Nangaku, LG Navar, A Nishiyama - Pharmacological reviews, 2007 - ASPET
In recent years, the focus of interest on the role of the renin-angiotensin system (RAS) in the
pathophysiology of hypertension and organ injury has changed to a major emphasis on the …

Sex and the renin-angiotensin system: inequality between the sexes in response to RAS stimulation and inhibition

JC Sullivan - American Journal of Physiology-Regulatory …, 2008 - journals.physiology.org
The purpose of this review is to examine sex differences in response to stimulation and
inhibition of the renin-angiotensin system (RAS). The RAS plays a prominent role in the …

Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension

JL Grobe, AP Mecca, H Mao… - American Journal of …, 2006 - journals.physiology.org
Cardiac remodeling is a hallmark hypertension-induced pathophysiology. In the current
study, the role of the angiotensin-(1–7) fragment in modulating cardiac remodeling was …

Angiotensin-(1–7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats

IF Benter, MHM Yousif, GS Dhaunsi, J Kaur… - American journal of …, 2007 - karger.com
Abstract Background/Aim: We examined the influence of chronic treatment with angiotensin-
(1–7)[Ang-(1–7)] on renox (renal NADPH oxidase, NOX-4) and the development of renal …

Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E–Deficient mice

S Tesanovic, A Vinh, TA Gaspari, D Casley… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—To evaluate the effectiveness of long-term angiotensin (Ang)(1-7) treatment to
inhibit the progression of atherosclerosis in apolipoprotein E-deficient (ApoE−/−) mice …

The importance of the intrarenal renin–angiotensin system

JCQ Velez - Nature clinical practice Nephrology, 2009 - nature.com
Evidence suggests that virtually every organ system in the human body possesses a local
renin–angiotensin system (RAS). These local systems seem to be independently regulated …

Chronic angiotensin (1–7) injection accelerates STZ‐induced diabetic renal injury1

Y Shao, M He, L Zhou, T Yao… - Acta Pharmacologica …, 2008 - Wiley Online Library
Aim: The renin‐angiotensin system (RAS) plays a critical role in blood pressure control and
body fluid and electrolyte homeostasis. In the past few years, angio‐tensin (Ang)(1–7) has …

Macrophages in neuroinflammation: role of the renin-angiotensin-system

A Hammer, J Stegbauer, RA Linker - Pflügers Archiv-European Journal of …, 2017 - Springer
Macrophages are essential players of the innate immune system which are involved in the
initiation and progression of various inflammatory and autoimmune diseases including …

Neurohumoral effects of the new orally active renin inhibitor, aliskiren, in chronic heart failure

A Seed, R Gardner, J McMurray… - European journal of …, 2007 - Wiley Online Library
Background Suppression of the renin–angiotensin–aldosterone system (RAAS) is
therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a …