Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma …

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of
metazoans and is important in many diseases. Integrin adhesion receptors can rapidly …

SARS-CoV-2 infection depends on binding its spike (S) protein to angiotensin-converting
enzyme 2 (ACE2). The S protein expresses an RGD motif, suggesting that integrins may be …

The complete ectodomain of integrin α IIb β 3 reveals a bent, closed, low-affinity
conformation, the β knee, and a mechanism for linking cytoskeleton attachment to high …

Integrins are a family of α/β heterodimeric adhesion metalloprotein receptors and their
functions are highly dependent on and regulated by different divalent cations. Recently …

Heterodimeric integrin adhesion receptors regulate cell migration, survival and
differentiation in metazoa by communicating signals bi‐directionally across the plasma …

Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-
bound conformations of the αIIbβ3 integrin headpiece. Starting from the closed βI domain …