The lymphatic vascular system develops from the pre-existing blood vasculature of the
vertebrate embryo. New insights into lymphatic vascular development have recently been …

Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

Establishment of a functional vascular network is rate-limiting in embryonic development,
tissue repair and engineering. During blood vessel formation, newly generated endothelial …

Lymphatic vasculature regulates fluid homeostasis by returning interstitial fluid to blood
circulation. Lymphatic endothelial cells (LECs) are the building blocks of the entire lymphatic …

The formation and remodeling of a functional circulatory system is critical for sustaining
prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells …

Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in
the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically …

Lymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs).
Despite their vital importance, the architecture and development of LVVs is poorly …

Chronic venous disease (CVD) has a range of clinical presentations, including tortuous,
distended veins in lower extremities, increasing skin pigmentation, and in severe cases …

Simple Summary Atrial fibrillation (AF) represents a worldwide medical problem contributing
to substantial morbidity, mortality and social-economic burden. Gap junctions and their …

The lymphatic vasculature is an integral component of the immune system. Lymphatic
vessels are a key highway via which immune cells are trafficked, serving not simply as a …