Engineered extracellular vesicles for cancer therapy

X Zhang, H Zhang, J Gu, J Zhang, H Shi… - Advanced …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) have emerged as a novel cell‐free strategy for the treatment of
many diseases including cancer. As a result of their natural properties to mediate cell‐to‐cell …

Mesenchymal stem cells-derived exosomes for drug delivery

Y Sun, G Liu, K Zhang, Q Cao, T Liu, J Li - Stem cell research & therapy, 2021 - Springer
Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid
bilayers without organelles. In recent years, an increasing number of researchers have …

Polydopamine decorated microneedles with Fe‐MSC‐derived nanovesicles encapsulation for wound healing

W Ma, X Zhang, Y Liu, L Fan, J Gan, W Liu… - Advanced …, 2022 - Wiley Online Library
Wound dressing with the capacities of antioxidation, antiinflammation, and efficient
angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

HY Kim, TJ Kim, L Kang, YJ Kim, MK Kang, J Kim… - Biomaterials, 2020 - Elsevier
Exosomes and extracellular nanovesicles (NV) derived from mesenchymal stem cells (MSC)
may be used for the treatment of ischemic stroke owing to their multifaceted therapeutic …

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

C Liu, F Hu, G Jiao, Y Guo, P Zhou, Y Zhang… - Journal of …, 2022 - Springer
Stem cell-derived exosomes have recently been regarded as potential drugs for treating
spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 …

Bioinspired exosome-like therapeutics and delivery nanoplatforms

M Lu, Y Huang - Biomaterials, 2020 - Elsevier
Exosomes have emerged as appealing candidate therapeutic agents and delivery
nanoplatforms due to their endogenous features and unique biological properties. However …

Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …

[HTML][HTML] Extracellular vesicles as bioactive nanotherapeutics: an emerging paradigm for regenerative medicine

M Li, F Fang, M Sun, Y Zhang, M Hu, J Zhang - Theranostics, 2022 - ncbi.nlm.nih.gov
In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles
which are involved in various physiological and pathological processes including cell …

Iron oxide nanoparticles in regenerative medicine and tissue engineering

RP Friedrich, I Cicha, C Alexiou - Nanomaterials, 2021 - mdpi.com
In recent years, many promising nanotechnological approaches to biomedical research
have been developed in order to increase implementation of regenerative medicine and …