Off-target effects of systemically administered drugs have been a major hurdle in designing
therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to …

This review is an updated and expanded version of the three prior reviews that were
published in this journal in 1997, 2003, and 2007. In the case of all approved therapeutic …

Abstract Structure determination of linear peptides of 5–50 amino acids in aqueous solution
and interacting with proteins is a key aspect in structural biology. PEP-FOLD3 is a novel …

Protein–peptide interactions play a crucial role in many cellular and biological functions,
which justify the increasing interest in the development of peptide-based drugs. However …

In the context of the renewed interest of peptides as therapeutics, it is important to have an
on-line resource for 3D structure prediction of peptides with well-defined structures in …

Peptide–nanoparticle conjugates (PNCs) have recently emerged as a versatile tool for
biomedical applications. Synergism between the two promising classes of materials allows …

The emergence and convergence of cancer genomics, targeted therapies, and network
oncology have significantly expanded the landscape of protein–protein interaction (PPI) …

Peptide–protein interactions are among the most prevalent and important interactions in the
cell, but a large fraction of those interactions lack detailed structural characterization. The …

The peptide quantitative structure–activity relationship (QSAR), also known as the
quantitative sequence–activity model (QSAM), has attracted much attention in the bio-and …

Conspectus Noble metal nanoparticles (NMNPs) have become firmly established as
effective agents to detect various biomolecules with extremely high sensitivity. This ability …