Epigenetics refers to the study of heritable changes in gene expression that occur without a
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …

In recent years, subtelomeric rearrangements have been identified as a major cause of
mental retardation and/or malformation syndromes. So far, over 2500 subjects with mental …

Abstract Silver-Russell syndrome (SRS, OMIM 180860) is a congenital disorder
characterized by severe intrauterine and postnatal growth retardation, dysmorphic facial …

Abstract Context: Russell-Silver syndrome (RSS), characterized by intrauterine and
postnatal growth retardation, dysmorphic features, and frequent body asymmetry, spares …

To investigate the function of the Grb10 adapter protein, we have generated mice in which
the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 …

Mutations in FOXP2 cause developmental verbal dyspraxia (DVD), but only a few cases
have been described. We characterize 13 patients with DVD—5 with hemizygous paternal …

Background: Silver–Russell syndrome (SRS) is a clinically and genetically heterogeneous
condition characterised by severe intrauterine and postnatal growth retardation. Loss of …

Silver–Russell syndrome (SRS MIM180860) is a disorder characterised by intrauterine
and/or postnatal growth restriction and typical facies. However, the clinical picture is …

The Grb proteins (growth factor receptor-bound proteins) Grb7, Grb10 and Grb14 constitute
a family of structurally related multidomain adapters with diverse cellular functions. Grb10 …

Grb10/GRB10 encodes a cytoplasmic adapter protein which modulates coupling of a
number of cell surface receptor tyrosine kinases with specific signalling pathways. Mouse …