Aliphatic polycarbonates have gained increased attention as biomaterials largely owing to
their biocompatibility and tunable degradation. Moreover, the ability to introduce functional …

Polymer–drug conjugates have long been a mainstay of the drug delivery field, with several
conjugates successfully translated into clinical practice. The conjugation of therapeutic …

Covalent modification of therapeutic compounds is a clinically proven strategy to devise
prodrugs with enhanced treatment efficacies. This prodrug strategy relies on the modified …

Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

The therapeutic efficacy of nanoscale anticancer drug delivery systems is severely truncated
by their low tumor-targetability and inefficient drug release at the target site. Here, we report …

In tumor tissues, reactive oxygen species (ROS) level is significantly higher than that in
normal tissues, which has been frequently explored as the specific stimulus to trigger drug …

Most chemotherapeutics are hydrophobic molecules and need to be converted into
hydrophilic form before administration. Based on the excellent hydrophilicity and …

An electrochemically driven, nickel-catalyzed reductive coupling of N-hydroxyphthalimide
esters with aryl halides is reported. The reaction proceeds under mild conditions in a divided …

We report a camptothecin (CPT) prodrug that was well formulated in solution and rapidly
transformed into long-circulating nanocomplexes in vivo for highly efficient drug delivery and …

Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …