Click Chemistry for Biofunctional Polymers: From Observing to Steering Cell Behavior
Click chemistry has become one of the most powerful construction tools in the field of
organic chemistry, materials science, and polymer science, as it offers hassle-free platforms …
organic chemistry, materials science, and polymer science, as it offers hassle-free platforms …
Multivalent glycans for biological and biomedical applications
Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2021 - pubs.rsc.org
Recognition of glycans by proteins plays a crucial role in a variety of physiological
processes in cells and living organisms. In addition, interactions of glycans with proteins are …
processes in cells and living organisms. In addition, interactions of glycans with proteins are …
Biocatalyzed synthesis of glycostructures with anti-infective activity
Conspectus Molecules containing carbohydrate moieties play essential roles in fighting a
variety of bacterial and viral infections. Consequently, the design of new carbohydrate …
variety of bacterial and viral infections. Consequently, the design of new carbohydrate …
Highly efficient functionalization of hydroxypropyl cellulose with glucuronic acid through click chemistry under microwave irradiation as potential biomaterial with …
A straightforward and effective method to chemically conjugate hydroxypropyl cellulose
(HPC) to GlcA is described via microwave assisted copper-catalyzed azide-alkyne …
(HPC) to GlcA is described via microwave assisted copper-catalyzed azide-alkyne …
Synthesis of glycodendrimers with antiviral and antibacterial activity
Glycodendrimers are an important class of synthetic macromolecules that can be used to
mimic many structural and functional features of cell‐surface glycoconjugates. Their …
mimic many structural and functional features of cell‐surface glycoconjugates. Their …
Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics
J O'Sullivan, J Muñoz-Muñoz, G Turnbull, N Sim… - RSC …, 2022 - pubs.rsc.org
Nucleic Acid Therapeutics (NATs) are establishing a leading role for the management and
treatment of genetic diseases following FDA approval of nusinersen, patisiran, and givosiran …
treatment of genetic diseases following FDA approval of nusinersen, patisiran, and givosiran …
Exploring Rigid and Flexible Scaffolds to Develop Potent Glucuronic Acid Glycodendrimers for Dengue Virus Inhibition
A Merchán, P Ramírez-López, C Martínez… - Bioconjugate …, 2023 - ACS Publications
Multivalent glycodendrimers are valuable tools for studying carbohydrate–protein
interactions, and their scaffolds represent important components to increase specificity and …
interactions, and their scaffolds represent important components to increase specificity and …
Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction
C García-Oliva, A Merchán, A Perona… - New Journal of …, 2022 - pubs.rsc.org
Two green strategies for copper-catalyzed azide–alkyne cycloaddition reaction based on
two activation pathways, solvent free mechanochemistry and microwave irradiation using a …
two activation pathways, solvent free mechanochemistry and microwave irradiation using a …
[HTML][HTML] Expanding the synthesis of a library of potent glucuronic acid glycodendrons for Dengue virus inhibition
Multivalent glycodendrons are valuable tools to mimic many structural and functional
features of cell-surface glycoconjugates and its focal position scaffolds represent important …
features of cell-surface glycoconjugates and its focal position scaffolds represent important …
GAG multivalent systems to interact with Langerin
Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a
pivotal role protecting organisms against pathogen infections. To address this aim, Langerin …
pivotal role protecting organisms against pathogen infections. To address this aim, Langerin …