Click Chemistry for Biofunctional Polymers: From Observing to Steering Cell Behavior

K Ghosal, SK Bhattacharyya, V Mishra… - Chemical …, 2024 - ACS Publications
Click chemistry has become one of the most powerful construction tools in the field of
organic chemistry, materials science, and polymer science, as it offers hassle-free platforms …

Multivalent glycans for biological and biomedical applications

Y Kim, JY Hyun, I Shin - Chemical Society Reviews, 2021 - pubs.rsc.org
Recognition of glycans by proteins plays a crucial role in a variety of physiological
processes in cells and living organisms. In addition, interactions of glycans with proteins are …

Biocatalyzed synthesis of glycostructures with anti-infective activity

P Hoyos, A Perona, T Bavaro, F Berini… - Accounts of Chemical …, 2022 - ACS Publications
Conspectus Molecules containing carbohydrate moieties play essential roles in fighting a
variety of bacterial and viral infections. Consequently, the design of new carbohydrate …

Highly efficient functionalization of hydroxypropyl cellulose with glucuronic acid through click chemistry under microwave irradiation as potential biomaterial with …

A Flores, D Cañamares, LA Ticona, JL Pablos, J Peña… - Catalysis Today, 2024 - Elsevier
A straightforward and effective method to chemically conjugate hydroxypropyl cellulose
(HPC) to GlcA is described via microwave assisted copper-catalyzed azide-alkyne …

Synthesis of glycodendrimers with antiviral and antibacterial activity

P Hoyos, A Perona, O Juanes… - … A European Journal, 2021 - Wiley Online Library
Glycodendrimers are an important class of synthetic macromolecules that can be used to
mimic many structural and functional features of cell‐surface glycoconjugates. Their …

Beyond GalNAc! Drug delivery systems comprising complex oligosaccharides for targeted use of nucleic acid therapeutics

J O'Sullivan, J Muñoz-Muñoz, G Turnbull, N Sim… - RSC …, 2022 - pubs.rsc.org
Nucleic Acid Therapeutics (NATs) are establishing a leading role for the management and
treatment of genetic diseases following FDA approval of nusinersen, patisiran, and givosiran …

Exploring Rigid and Flexible Scaffolds to Develop Potent Glucuronic Acid Glycodendrimers for Dengue Virus Inhibition

A Merchán, P Ramírez-López, C Martínez… - Bioconjugate …, 2023 - ACS Publications
Multivalent glycodendrimers are valuable tools for studying carbohydrate–protein
interactions, and their scaffolds represent important components to increase specificity and …

Development of sustainable synthesis of glucuronic acid glycodendrimers using ball milling and microwave-assisted CuAAC reaction

C García-Oliva, A Merchán, A Perona… - New Journal of …, 2022 - pubs.rsc.org
Two green strategies for copper-catalyzed azide–alkyne cycloaddition reaction based on
two activation pathways, solvent free mechanochemistry and microwave irradiation using a …

[HTML][HTML] Expanding the synthesis of a library of potent glucuronic acid glycodendrons for Dengue virus inhibition

P Ramírez-López, C Martínez, A Merchán, A Perona… - Bioorganic …, 2023 - Elsevier
Multivalent glycodendrons are valuable tools to mimic many structural and functional
features of cell-surface glycoconjugates and its focal position scaffolds represent important …

GAG multivalent systems to interact with Langerin

J Rojo, PM Nieto, JL de Paz - Current Medicinal Chemistry, 2022 - benthamdirect.com
Langerin is a C-type Lectin expressed at the surface of Langerhans cells, which play a
pivotal role protecting organisms against pathogen infections. To address this aim, Langerin …