[HTML][HTML] Mitochondrial degradation: Mitophagy and beyond

L Uoselis, TN Nguyen, M Lazarou - Molecular cell, 2023 - cell.com
Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

[HTML][HTML] Cannabidiol (CBD) as a promising anti-cancer drug

ES Seltzer, AK Watters, D MacKenzie, LM Granat… - Cancers, 2020 - mdpi.com
Recently, cannabinoids, such as cannabidiol (CBD) and Δ 9-tetrahydrocannabinol (THC),
have been the subject of intensive research and heavy scrutiny. Cannabinoids encompass a …

[HTML][HTML] Cannabinoids as anticancer drugs: current status of preclinical research

B Hinz, R Ramer - British journal of cancer, 2022 - nature.com
Drugs that target the endocannabinoid system are of interest as pharmacological options to
combat cancer and to improve the life quality of cancer patients. From this perspective …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[HTML][HTML] Phenolic metabolites as therapeutic in inflammation and neoplasms: Molecular pathways explaining their efficacy

W Liu, X Cui, Y Zhong, R Ma, B Liu, Y Xia - Pharmacological research, 2023 - Elsevier
Polyphenols, also known as phenolic compounds, are chemical substances containing
aromatic rings as well as at least two hydroxyl groups. Natural phenolic compounds exist …

[HTML][HTML] Cannabidiol (CBD): A killer for inflammatory rheumatoid arthritis synovial fibroblasts

T Lowin, R Tingting, J Zurmahr, T Classen… - Cell death & …, 2020 - nature.com
Cannabidiol (CBD) is a non-intoxicating phytocannabinoid from cannabis sativa that has
demonstrated anti-inflammatory effects in several inflammatory conditions including arthritis …

[HTML][HTML] Molecular and cellular mechanisms of action of cannabidiol

N Martinez Naya, J Kelly, G Corna, M Golino, A Abbate… - Molecules, 2023 - mdpi.com
Cannabidiol (CBD) is the primary non-psychoactive chemical from Cannabis Sativa, a plant
used for centuries for both recreational and medicinal purposes. CBD lacks the psychotropic …

[HTML][HTML] Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer

AM Mahmoud, M Kostrzewa, V Marolda… - Pharmacological …, 2023 - Elsevier
In spite of the huge advancements in both diagnosis and interventions, hormone refractory
prostate cancer (HRPC) remains a major hurdle in prostate cancer (PCa). Metabolic …

[HTML][HTML] Regulatory effects of cannabidiol on mitochondrial functions: a review

JZ Chan, RE Duncan - Cells, 2021 - mdpi.com
Cannabidiol (CBD) is part of a group of phytocannabinoids derived from Cannabis sativa.
Initial work on CBD presumed the compound was inactive, but it was later found to exhibit …

Cannabidiol and abnormal liver chemistries in healthy adults: results of a phase I clinical trial

PB Watkins, RJ Church, J Li… - Clinical Pharmacology & …, 2021 - Wiley Online Library
Liver safety concerns were raised in randomized controlled trials of cannabidiol (CBD) in
patients with Lennox‐Gastaut and Dravet syndromes, but the relevance of these concerns to …