Dysregulation of the epigenetic processes, such as DNA methylation, histone modifications,
and modulation of chromatin states, drives aberrant transcription that promotes initiation and …

Lung cancer is the top reason for cancer-related deaths worldwide. The 5-year overall
survival rate of lung cancer is approximately 20% due to the delayed diagnosis and low …

Prodrug is a potential regime to overcome serious adverse events and off-target effects of
chemotherapy agents. Among various prodrug activators, hypoxia stands out owing to the …

DNA damage response and repair (DDR) gene alterations increase tumor-infiltrating
lymphocytes, genomic instability, and tumor mutational burden (TMB). Whether DDR-related …

Background Anti-PD-1 (L1) therapies are less efficacious in patients with EGFR-mutated non-
small-cell lung cancer. However, the underlying mechanism is poorly understood. Methods …

Background OX40 and OX40 ligand (OX40L), as essential immune checkpoint (IC)
modulators, are highly correlated with cancer immunity regulation as well as tumor …

Background The prognosis of non-small cell lung cancer (NSCLC) patients has been
comprehensively studied. However, the prognosis of resectable (stage I–IIIA) lung …

Background Prognostic models based on multiomics data may provide better predictive
capability than those established at the single-omics level. Here we aimed to establish a …

Objective Lung cancer is classified into central and peripheral types based on the anatomic
location. The present study aimed to explore the distinct patterns of genomic alterations …

Tumor-infiltrating lymphocytes (TILs) are essential components of the tumor
microenvironment (TME) of non-small cell lung cancer (NSCLC). Still, it is difficult to describe …