Heart failure (HF) is an acute or chronic clinical syndrome that results in a decrease in
cardiac output and an increase in intracardiac pressure at rest or upon exertion. The …

Various pathophysiological mechanisms have been implicated in hypertension, but those
resulting in vascular dysfunction and remodeling are critical and may help to identify critical …

For vascular remodeling in hypertension, it is essential that vascular smooth muscle cells
(VSMCs) reshape in order to proliferate and migrate. The extracellular matrix (ECM) needs …

Stroke is the second leading cause of mortality and morbidity worldwide. Early intervention
is of great importance in reducing disease burden. Since the conventional risk factors cannot …

This MiniReview describes the essential biochemical and molecular aspects of matrix
metalloproteinases (MMP s) and briefly discusses how they engage in different diseases …

Growing experimental evidence indicates that matrix metalloproteinases (MMPs) are
implicated in many cardiovascular diseases including hypertension and its chronic …

Hypertension is associated with well known structural and functional alterations in both
resistance and conduit arteries, which may be the result from long-lasting high blood …

Hypertension is characterized by maladaptive vascular remodeling and enhanced oxidative
stress in the vascular wall. Peroxynitrite may directly activate latent matrix metalloproteinase …

Preeclampsia is an important syndrome complicating pregnancy. While the pathogenesis of
preeclampsia is not entirely known, poor placental perfusion leading to widespread …

A group of proteases, the matrix metalloproteinases (MMPs) are well known for their
capacity to degrade extracellular matrix (ECM) proteins. Particularly MMP-2 and MMP-9 …