Polymeric nanoparticle vaccines to combat emerging and pandemic threats

D Wibowo, SHT Jorritsma, ZJ Gonzaga, B Evert… - Biomaterials, 2021 - Elsevier
Subunit vaccines are more advantageous than live attenuated vaccines in terms of safety
and scale-up manufacture. However, this often comes as a trade-off to their efficacy. Over …

Nanomaterial-based delivery of vaccine through nasal route: opportunities, challenges, advantages, and limitations

M Kumar, R Dogra, UK Mandal - Journal of Drug Delivery Science and …, 2022 - Elsevier
Mucosal administration especially via the nasal route is a novel and promising technique for
medication and vaccine delivery. Mucosal pathways provide notable benefits that promote …

Aluminum-based metal–organic framework nanoparticles as pulmonary vaccine adjuvants

ZS Stillman, GE Decker, MR Dworzak, ED Bloch… - Journal of …, 2023 - Springer
The adoption of pulmonary vaccines to advantageously provide superior local mucosal
protection against aerosolized pathogens has been faced with numerous logistical and …

Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy

JC Ma, T Luo, B Feng, Z Huang, Y Zhang… - Journal of …, 2023 - Springer
Osteoarthritis (OA) is a prevalent joint disease that affects all the tissues within the joint and
currently lacks disease-modifying treatments in clinical practice. Despite the potential of …

Biomaterials and nanomaterials for sustained release vaccine delivery

MA Luzuriaga, A Shahrivarkevishahi… - Wiley …, 2021 - Wiley Online Library
Vaccines are considered one of the most significant medical advancements in human
history, as they have prevented hundreds of millions of deaths since their discovery; …

Long-term vaccine delivery and immunological responses using biodegradable polymer-based carriers

A Malek-Khatabi, Z Tabandeh, A Nouri… - ACS Applied Bio …, 2022 - ACS Publications
Biodegradable polymers are largely employed in the biomedical field, ranging from tissue
regeneration to drug/vaccine delivery. The biodegradable polymers are highly …

Combined adjuvant-delivery system for new generation vaccine antigens: alliance has its own advantage

M Kaurav, J Madan, MS Sudheesh… - Artificial Cells …, 2018 - Taylor & Francis
Vaccines are a significant historical accomplishment in medical science due to its
significance in saving millions of lives around the world with a manifold decline in disease …

Polyethyleneimine-based immunoadjuvants for designing cancer vaccines

X Yang, Y Wei, L Zheng, J You, H Li, L Gao… - Journal of Materials …, 2022 - pubs.rsc.org
Despite extensive efforts to improve the effectiveness of cancer vaccines, the lack of
immunogenicity remains an issue. Adjuvants are required to enhance the immunogenicity of …

Technological approaches for improving vaccination compliance and coverage

C Lemoine, A Thakur, D Krajišnik, R Guyon, S Longet… - Vaccines, 2020 - mdpi.com
Vaccination has been well recognised as a critically important tool in preventing infectious
disease, yet incomplete immunisation coverage remains a major obstacle to achieving …

Microneedle arrays for vaccine delivery: the possibilities, challenges and use of nanoparticles as a combinatorial approach for enhanced vaccine immunogenicity

AM Rodgers, AS Cordeiro… - Expert Opinion on …, 2018 - Taylor & Francis
Introduction: Vaccination is one of the greatest breakthroughs of modern preventative
medicine. Despite this, there remain problems surrounding delivery, efficacy and …