Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet
of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Abstract Phosphatidylinositol (4, 5) bisphosphate (PI (4, 5) P2) has become a major focus in
biochemistry, cell biology and physiology owing to its diverse functions at the plasma …

Phosphoinositides serve as signature motifs for different cellular membranes and often are
required for the function of membrane proteins. Here, we summarize clear evidence …

Long-chain acyl-coenzyme A (LC-CoA) is a crucial metabolic intermediate that plays
important cellular regulatory roles, including activation and inhibition of ion channels. The …

Phosphoinositides (PIs) are lipid components of cell membranes that regulate a wide variety
of cellular functions. Here we exploited the blue light-induced dimerization between two …

Fluorescence has long been recognized as a powerful tool for probing biological structure
and function. Nearly sixty-five years ago, Coons and colleagues introduced the first …

Phosphoinositides are a family of minority acidic phospholipids in cell membranes. Their
principal role is instructional: they interact with proteins. Each cellular membrane …

Lipids play an important role in physiology and pathophysiology of living systems. Until a
few decades ago, the number of lipid molecules that were chemically characterized was a …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …