Regulation of Viral Infection by the RNA Modification N6-Methyladenosine
GD Williams, NS Gokhale… - Annual review of virology, 2019 - annualreviews.org
In recent years, the RNA modification N6-methyladenosine (m6A) has been found to play a
role in the life cycles of numerous viruses and also in the cellular response to viral infection …
role in the life cycles of numerous viruses and also in the cellular response to viral infection …
RNA-binding proteins control gene expression and cell fate in the immune system
M Turner, MD Díaz-Muñoz - Nature immunology, 2018 - nature.com
RNA-binding proteins (RBPs) are essential for the development and function of the immune
system. They interact dynamically with RNA to control its biogenesis and turnover by …
system. They interact dynamically with RNA to control its biogenesis and turnover by …
[HTML][HTML] Elimination of toxic microsatellite repeat expansion RNA by RNA-targeting Cas9
Microsatellite repeat expansions in DNA produce pathogenic RNA species that cause
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
dominantly inherited diseases such as myotonic dystrophy type 1 and 2 (DM1/2) …
Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing
Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene
variants that individually have minimal effect sizes. As environmental factors that perturb …
variants that individually have minimal effect sizes. As environmental factors that perturb …
[HTML][HTML] Cellular stress alters 3′ UTR landscape through alternative polyadenylation and isoform-specific degradation
Most eukaryotic genes express alternative polyadenylation (APA) isoforms with different 3′
UTR lengths, production of which is influenced by cellular conditions. Here, we show that …
UTR lengths, production of which is influenced by cellular conditions. Here, we show that …
Unconventional viral gene expression mechanisms as therapeutic targets
Unlike the human genome that comprises mostly noncoding and regulatory sequences,
viruses have evolved under the constraints of maintaining a small genome size while …
viruses have evolved under the constraints of maintaining a small genome size while …
The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1
Myotonic dystrophy type I (DM1) is a multisystemic autosomal-dominant inherited human
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
disorder that is caused by CTG microsatellite repeat expansions (MREs) in the 3 …
Uncovering the role of RNA-binding proteins in gene expression in the immune system
MD Díaz-Muñoz, M Turner - Frontiers in immunology, 2018 - frontiersin.org
Fighting external pathogens requires an ever-changing immune system that relies on tight
regulation of gene expression. Transcriptional control is the first step to build efficient …
regulation of gene expression. Transcriptional control is the first step to build efficient …
Viral-induced alternative splicing of host genes promotes influenza replication
MG Thompson, M Dittmar, MJ Mallory, P Bhat… - Elife, 2020 - elifesciences.org
Viral infection induces the expression of numerous host genes that impact the outcome of
infection. Here, we show that infection of human lung epithelial cells with influenza A virus …
infection. Here, we show that infection of human lung epithelial cells with influenza A virus …
Human cytomegalovirus genomics and transcriptomics through the lens of next-generation sequencing: revision and future challenges
J Martí-Carreras, P Maes - Virus Genes, 2019 - Springer
The human cytomegalovirus (HCMV) genome was sequenced by hierarchical shotgun
almost 30 years ago. Over these years, low and high passaged strains have been …
almost 30 years ago. Over these years, low and high passaged strains have been …