The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism

V Prevot, B Dehouck, A Sharif, P Ciofi… - Endocrine …, 2018 - academic.oup.com
The fertility and survival of an individual rely on the ability of the periphery to promptly,
effectively, and reproducibly communicate with brain neural networks that control …

Astrocytes: GABAceptive and GABAergic cells in the brain

J Liu, X Feng, Y Wang, X Xia, JC Zheng - Frontiers in cellular …, 2022 - frontiersin.org
Astrocytes, the most numerous glial cells in the brain, play an important role in preserving
normal neural functions and mediating the pathogenesis of neurological disorders. Recent …

The role of glia in the physiology and pharmacology of glucagon‐like peptide‐1: implications for obesity, diabetes, neurodegeneration and glaucoma

QN Cui, LM Stein, SM Fortin… - British Journal of …, 2022 - Wiley Online Library
The medical applications of glucagon‐like peptide‐1 receptor (GLP‐1R) agonists is
evergrowing in scope, highlighting the urgent need for a comprehensive understanding of …

Acyl-CoA binding protein for the experimental treatment of anorexia

H Chen, S Moriceau, A Joseph, F Mailliet, S Li… - Science Translational …, 2024 - science.org
Extracellular acyl-coenzyme A binding protein [ACBP encoded by diazepam binding
inhibitor (DBI)] is a phylogenetically ancient appetite stimulator that is secreted in a …

GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats

SM Fortin, RK Lipsky, R Lhamo, J Chen… - Science translational …, 2020 - science.org
The glucagon-like peptide-1 receptor (GLP-1R) agonist liraglutide is approved for the
treatment of obesity; however, there is still much to be learned regarding the neuronal sites …

Endozepines and their receptors: structure, functions and pathophysiological significance

MC Tonon, H Vaudry, J Chuquet, F Guillebaud… - Pharmacology & …, 2020 - Elsevier
The existence of specific binding sites for benzodiazepines (BZs) in the brain has prompted
the search for endogenous BZ receptor ligands designated by the generic term …

Acyl coenzyme A binding protein (ACBP): An aging‐and disease‐relevant “autophagy checkpoint”

L Montégut, M Abdellatif, O Motiño, F Madeo… - Aging …, 2023 - Wiley Online Library
Acyl coenzyme A binding protein (ACBP), also known as diazepam‐binding inhibitor (DBI),
is a phylogenetically ancient protein present in some eubacteria and the entire eukaryotic …

The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system

K Bouyakdan, H Martin, F Liénard… - The Journal of …, 2019 - Am Soc Clin Investig
Glial cells have emerged as key players in the central control of energy balance and etiology
of obesity. Astrocytes play a central role in neural communication via the release of …

Emerging roles of brain tanycytes in regulating blood–hypothalamus barrier plasticity and energy homeostasis

H Kannangara, L Cullen, S Miyashita… - Annals of the New …, 2023 - Wiley Online Library
Seasonal changes in food intake and adiposity in many animal species are triggered by
changes in the photoperiod. These latter changes are faithfully transduced into a …

Old paradoxes and new opportunities for appetite control in obesity

L Montégut, C Lopez-Otin, C Magnan… - Trends in Endocrinology & …, 2021 - cell.com
Human obesity is accompanied by alterations in the blood concentrations of multiple
circulating appetite regulators. Paradoxically, most of the appetite-inhibitory hormones are …