The pathogenesis of periodontitis involves a complex immune/inflammatory cascade that is
initiated by the bacteria of the oral biofilm that forms naturally on the teeth. The susceptibility …

Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

Introduction: Periodontal disease is a chronic inflammation of the attachment structures of
the teeth, triggered by potentially hazardous microorganisms and the consequent immune …

MicroRNAs (miRNAs) have been demonstrated to play an important role in regulation of the
immuno‐inflammatory response; however, the function of miRNAs in periodontal …

Garlet GP, Cardoso CR, Mariano FS, Claudino M, de Assis GF, Campanelli AP, Ávila‐
Campos MJ, Silva JS. Regulatory T cells attenuate experimental periodontitis progression in …

Background and Objective Tumor necrosis factor alpha (TNF‐α), a cytokine involved in the
pathogenesis of periodontal disease, induces osteoclast differentiation and indirectly …

Background: Tumor necrosis factor‐α (TNF‐α) plays a central role in the molecular
pathogenesis of periodontal disease. However, the epigenetic regulation attributable to …

Receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) are
expressed in apical periodontitis, suggesting a role for these molecules during lesion …

Recently, new treatment approaches have been developed to target the host component of
periodontal disease. This review aims at providing updated information on host-modulating …

SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is
relevant in inflammatory conditions. We used a model of LPS‐induced periodontal disease …