Genomic frontiers in congenital heart disease
The application of next-generation sequencing to study congenital heart disease (CHD) is
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
increasingly providing new insights into the causes and mechanisms of this prevalent birth …
The deployment of cell lineages that form the mammalian heart
SM Meilhac, ME Buckingham - Nature Reviews Cardiology, 2018 - nature.com
The function of the mammalian heart depends on the interplay between different cardiac cell
types. The deployment of these cells, with precise spatiotemporal regulation, is also …
types. The deployment of these cells, with precise spatiotemporal regulation, is also …
Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST
Spatial transcriptomics technologies generate gene expression profiles with spatial context,
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …
requiring spatially informed analysis tools for three key tasks, spatial clustering, multisample …
Human pluripotent stem cell-derived atrial and ventricular cardiomyocytes develop from distinct mesoderm populations
The ability to direct the differentiation of human pluripotent stem cells (hPSCs) to the different
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …
Maturation of cardiac energy metabolism during perinatal development
J Piquereau, R Ventura-Clapier - Frontiers in physiology, 2018 - frontiersin.org
As one of the highest energy consumer organ in mammals, the heart has to be provided with
a high amount of energy as soon as its first beats in utero. During the development of this …
a high amount of energy as soon as its first beats in utero. During the development of this …
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a
powerful tool for human disease modeling and therapeutic testing. However, their use …
powerful tool for human disease modeling and therapeutic testing. However, their use …
Transcriptomic profiling maps anatomically patterned subpopulations among single embryonic cardiac cells
Embryonic gene expression intricately reflects anatomical context, developmental stage,
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …
and cell type. To address whether the precise spatial origins of cardiac cells can be deduced …
Building the mammalian heart from two sources of myocardial cells
M Buckingham, S Meilhac, S Zaffran - Nature Reviews Genetics, 2005 - nature.com
Cardiogenesis is an exquisitely sensitive process. Any perturbation in the cells that
contribute to the building of the heart leads to cardiac malformations, which frequently result …
contribute to the building of the heart leads to cardiac malformations, which frequently result …
Cardiac chamber formation: development, genes, and evolution
AFM Moorman, VM Christoffels - Physiological reviews, 2003 - journals.physiology.org
Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …
Building and re-building the heart by cardiomyocyte proliferation
The adult human heart does not regenerate significant amounts of lost tissue after injury.
Rather than making new, functional muscle, human hearts are prone to scarring and …
Rather than making new, functional muscle, human hearts are prone to scarring and …