Molecular mechanisms controlling vertebrate retinal patterning, neurogenesis, and cell fate specification
This review covers recent advances in understanding the molecular mechanisms controlling
neurogenesis and specification of the developing retina, with a focus on insights obtained …
neurogenesis and specification of the developing retina, with a focus on insights obtained …
[HTML][HTML] A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal Lamination
C Norden - Annual Review of Cell and Developmental Biology, 2023 - annualreviews.org
The neural retina, at the back of the eye, is a fascinating system to use to discover how cells
form tissues in the context of the developing nervous system. The retina is the tissue …
form tissues in the context of the developing nervous system. The retina is the tissue …
Neural stem cells to cerebral cortex: emerging mechanisms regulating progenitor behavior and productivity
This review accompanies a 2016 SFN mini-symposium presenting examples of current
studies that address a central question: How do neural stem cells (NSCs) divide in different …
studies that address a central question: How do neural stem cells (NSCs) divide in different …
[HTML][HTML] The symmetry of neural stem cell and progenitor divisions in the vertebrate brain
G Casas Gimeno, JTML Paridaen - Frontiers in Cell and …, 2022 - frontiersin.org
Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …
[HTML][HTML] An eye on the Wnt inhibitory factor Wif1
The coordinated interplay between extrinsic activating and repressing cell signaling
molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is …
molecules is pivotal for embryonic development and subsequent tissue homeostasis. This is …
Anillin is an emerging regulator of tumorigenesis, acting as a cortical cytoskeletal scaffold and a nuclear modulator of cancer cell differentiation
Remodeling of the intracellular cytoskeleton plays a key role in accelerating tumor growth
and metastasis. Targeting different cytoskeletal elements is important for existing and future …
and metastasis. Targeting different cytoskeletal elements is important for existing and future …
Deterministic and probabilistic fate decisions co‐exist in a single retinal lineage
Correct nervous system development depends on the timely differentiation of progenitor
cells into neurons. While the output of progenitor differentiation is well investigated at the …
cells into neurons. While the output of progenitor differentiation is well investigated at the …
Cortical PAR polarity proteins promote robust cytokinesis during asymmetric cell division
Cytokinesis, the physical division of one cell into two, is thought to be fundamentally similar
in most animal cell divisions and driven by the constriction of a contractile ring positioned …
in most animal cell divisions and driven by the constriction of a contractile ring positioned …
[HTML][HTML] ANLN enhances triple-negative breast cancer stemness through TWIST1 and BMP2 and promotes its spheroid growth
ANLN is frequently upregulated in triple-negative breast cancer (TNBC) and its high
expression in tumors are significantly associated with poor survival and recurrence, thereby …
expression in tumors are significantly associated with poor survival and recurrence, thereby …
[HTML][HTML] Anillin regulates breast cancer cell migration, growth, and metastasis by non-canonical mechanisms involving control of cell stemness and differentiation
Background Breast cancer metastasis is driven by a profound remodeling of the
cytoskeleton that enables efficient cell migration and invasion. Anillin is a unique scaffolding …
cytoskeleton that enables efficient cell migration and invasion. Anillin is a unique scaffolding …