Proteases are signaling molecules that specifically control cellular functions by cleaving
protease-activated receptors (PARs). The four known PARs are members of the large family …

Abstract Ossovskaya, Valeria S., and Nigel W. Bunnett. Protease-Activated Receptors:
Contribution to Physiology and Disease. Physiol Rev 84: 579–621, 2004; 10.1152/physrev …

This review focuses on the role of the peripheral nervous system in cutaneous biology and
disease. During the last few years, a modern concept of an interactive network between …

Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown
mechanisms, induce widespread inflammation. We found that a large proportion of primary …

Abstract Proteinase-activated receptors (PARs), a family of four seven-transmembrane G
protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs …

Protease-activated receptors (PARs) are G protein-coupled receptors that are activated by
proteolytical cleavage of the amino-terminus and thereby act as sensors for extracellular …

Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is
expressed on sensory nerves to cause neurogenic inflammation. Transient receptor …

Using a combined pharmacological and gene-deletion approach, we have delineated a
novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by …