Ionizing radiation biomarkers in epidemiological studies–an update

J Hall, PA Jeggo, C West, M Gomolka… - … Research/Reviews in …, 2017 - Elsevier
Recent epidemiology studies highlighted the detrimental health effects of exposure to low
dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown …

Mechanisms of radiation bystander and non-targeted effects: implications to radiation carcinogenesis and radiotherapy

R Yahyapour, E Motevaseli, A Rezaeyan… - Current …, 2018 - ingentaconnect.com
Background: Knowledge of radiobiology is of paramount importance to be able to grasp and
have an in-depth understanding of the consequences of ionizing radiation. One of the most …

FDXR is a biomarker of radiation exposure in vivo

G O'Brien, L Cruz-Garcia, M Majewski, J Grepl… - Scientific reports, 2018 - nature.com
Previous investigations in gene expression changes in blood after radiation exposure have
highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional …

Epigenetic modulation of inflammatory pathways in myometrial stem cells and risk of uterine fibroids

Q Yang, M Ali, LS Treviño, A Mas, N Ismail… - International Journal of …, 2023 - mdpi.com
The period during which tissue and organ development occurs is particularly vulnerable to
the influence of environmental exposures. However, the specific mechanisms through which …

Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review

J Lacombe, C Sima, SA Amundson, F Zenhausern - PloS one, 2018 - journals.plos.org
Purpose To compile a list of genes that have been reported to be affected by external
ionizing radiation (IR) and to assess their performance as candidate biomarkers for …

Early molecular markers for retrospective biodosimetry and prediction of acute health effects

M Abend, WF Blakely, P Ostheim… - Journal of …, 2022 - iopscience.iop.org
Radiation-induced biological changes occurring within hours and days after irradiation can
be potentially used for either exposure reconstruction (retrospective dosimetry) or the …

Quantitative changes in the protein and miRNA cargo of plasma exosome-like vesicles after exposure to ionizing radiation

R Yentrapalli, J Merl-Pham, O Azimzadeh… - … journal of radiation …, 2017 - Taylor & Francis
Purpose: Multiple cell types secrete exosome-like extracellular vesicles (ELVs) to the
extracellular environment. Pathological conditions can produce characteristic changes to the …

Activation of IGF-1/GLP-1 signalling via 4-hydroxyisoleucine prevents motor neuron impairments in experimental ALS-rats exposed to methylmercury-induced …

A Shandilya, S Mehan, S Kumar, P Sethi, AS Narula… - Molecules, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a severe adult motor neuron disease that causes
progressive neuromuscular atrophy, muscle wasting, weakness, and depressive-like …

Transcriptomics for radiation biodosimetry: progress and challenges

SA Amundson - International journal of radiation biology, 2023 - Taylor & Francis
Purpose Transcriptomic-based approaches are being developed to meet the needs for large-
scale radiation dose and injury assessment and provide population triage following a …

Analysis of lncRNA-miRNA-mRNA expression pattern in heart tissue after total body radiation in a mouse model

MJ Aryankalayil, S Martello, MA Bylicky… - Journal of Translational …, 2021 - Springer
Background Radiation therapy is integral to effective thoracic cancer treatments, but its
application is limited by sensitivity of critical organs such as the heart. The impacts of acute …